Hacker News with Generative AI: Medicine

Staphylococcus aureus 'steals' iron from our blood during infections (phys.org)
Researchers have revealed how Staphylococcus aureus bacteria extract iron from hemoglobin—a process crucial to their survival during infections.
Broken legs and ankles heal better if you walk on them within weeks (scientificamerican.com)
Twenty years ago my husband, Mark, broke his left ankle and was in a cast and on crutches for nearly two months. Last year he broke the other ankle. But this time, after surgery, his doctor surprised us by instructing Mark to walk on it two weeks later.
When Doctors with A.I. Are Outperformed by A.I. Alone (erictopol.substack.com)
A recent M.I.T.-Harvard study, of which one of us, Dr. Rajpurkar, is an author, examined how radiologists diagnose potential diseases from chest X-rays. The study found that when radiologists were shown A.I. predictions about the likelihood of disease, they often undervalued the A.I. input compared to their own judgment. The doctors stuck to their initial impressions even when the A.I. was correct, which led them to make less accurate diagnoses.
It's not just AI. China's medicines are surprising the world, too (economist.com)
It’s not just AI. China’s medicines are surprising the world, too
Scientists trace deadly cell-to-cell message chain that spreads in sepsis (phys.org)
Like a poison pen, dying cells prick their neighbors with a lethal message. This may worsen sepsis, Vijay Rathinam and colleagues in the UConn School of Medicine report in the Jan. 23 issue of Cell. Their findings could lead to a new understanding of this dangerous illness.
New obesity drugs are coming: these are the ones to watch (nature.com)
Dozens of new obesity drugs are coming: these are the ones to watch
Ozempic shows promise in reducing cravings for alcohol, heavy drinking (unchealthcare.org)
Dose-dependent effects of LSD in double-blind placebo-controlled study (2020) (nature.com)
Growing interest has been seen in using lysergic acid diethylamide (LSD) in psychiatric research and therapy.
Rethinking mental health: The body's impact on the brain (thetransmitter.org)
Psychiatric conditions have long been regarded as issues of “mental health,” a term that inherently ties our understanding of these disorders to the brain. But the brain does not exist in a vacuum. Growing evidence over the past 10 years highlights a link between the body and what we think of as mental health.
Cancer-fighting compound shows immense potential to eradicate HIV (news.stanford.edu)
The Physicians Are Healing Themselves, with Ozempic (nytimes.com)
At cardiology conferences and diabetes meetings, doctors can’t help noticing that thin seems to be very in.
The hallucinatory thoughts of the dying mind (mitpress.mit.edu)
Delirium is one of the most perplexing deathbed phenomena, exposing the gap between our cultural ideals of dying words and the reality of a disoriented mind.
Did UCLA Just Cure Baldness? (newsroom.ucla.edu)
UCLA scientists have now identified a small molecule that, when prompted, can waken long-slumbering but undamaged follicles.
AI tool helps find life-saving medicine for rare disease (pennmedicine.org)
After combing through 4,000 existing medications, an artificial intelligence tool helped uncover one that saved the life of a patient with idiopathic multicentric Castleman’s disease (iMCD).
You've Lost Weight Taking New Obesity Drugs. What Happens If You Stop? (nytimes.com)
Many patients are eager to discontinue Wegovy or Zepbound when their weight loss plateaus. But doctors say it’s difficult to go cold turkey.
Antibiotics, vaccinations linked to reduced risk of dementia (cam.ac.uk)
Antibiotics, antivirals, vaccinations and anti-inflammatory medication are associated with reduced risk of dementia, according to new research that looked at health data from over 130 million individuals.
FDA approves first new type of pain medication in 25 years (cnn.com)
Scientific Incentives Stalled the Fight Against Antibiotic Resistance (ifp.org)
If nothing is done, antibiotic resistance promises a return to the historical norm of more frequent death from infectious diseases.
The doctor who gave himself an ulcer and solved a medical mystery (2010) (discovermagazine.com)
For years an obscure doctor hailing from Australia’s hardscrabble west coast watched in horror as ulcer patients fell so ill that many had their stomach removed or bled until they died.
We may be taking blood pressure readings all wrong (arstechnica.com)
According to the study, published in JAMA Cardiology and led by researchers at Harvard, blood pressure readings measured while lying down were significantly better at indicating risks of cardiovascular disease, stroke, heart failure, and death than were seated blood pressure readings alone.
Obesity drugs: study highlights new health risks (nature.com)
Blockbuster obesity drugs such as Ozempic have been celebrated for their ability to treat weight loss and a surprising range of other conditions, from heart issues to Parkinson’s disease. Now, an analysis of data from nearly 2 million people is revealing new insights into the effects of these medications — including the risks they pose.
The Compounding Loophole (astralcodexten.com)
Now that we’ve gone over the pharmacology of the GLP-1 agonists, let’s get back to the economics.
De novo designed proteins neutralize lethal snake venom toxins (nature.com)
Snakebite envenoming remains a devastating and neglected tropical disease, claiming over 100,000 lives annually and causing severe complications and long-lasting disabilities for many more1,2.
Experts hail 'milestone' in study of the deadly Huntington's disease (abc.net.au)
AI-designed proteins tackle century-old problem – making snake antivenoms (nature.com)
Proteins designed using artificial intelligence (AI) can block the lethal effects of toxins delivered in the venom of cobras, adders and other deadly snakes.
Researchers use AI to design proteins that block snake venom toxins (arstechnica.com)
It's a good example of how computer developments can be used for practical problems.
Apple's Machine Learning Research can now detect Heart Murmurs with 95% accuracy (myhealthyapple.com)
Apple has been on the forefront of cardio tech since it rolled out the Apple Watch close to a decade ago. Many of the company’s innovations, such as atrial fibrillation detection and irregular heart-beat detection features have proven to be life saving.
Collection: More Doctors Smoke Camels (tobacco.stanford.edu)
One common technique used by the tobacco industry to reassure a worried public was to incorporate images of physicians in their ads.
Targeting Mosquito Spit Could Stop Parasites in Their Tracks (the-scientist.com)
A protein found in the saliva of Anopheles gambiae stopped blood from clotting in the insects’ stomachs and aided parasite transmission.
Scientists Discover Common Virus Could Be Causing a Type of Alzheimer's (sciencealert.com)
Researchers have discovered a link between a chronic gut infection caused by a common virus and the development of Alzheimer's disease in some people.