Hacker News with Generative AI: Medicine

'Vaguely Threatening': Federal Prosecutor Queries Leading Medical Journal (nytimes.com)
A federal prosecutor in Washington has contacted The New England Journal of Medicine, considered the world’s most prestigious medical journal, with questions that suggested without evidence that it was biased against certain views and influenced by external pressures.
Blocking a master regulator of immunity eradicates liver tumors in mice (med.stanford.edu)
A protein identified nearly 40 years ago for its ability to stimulate the production of red blood cells plays a surprising, critical role in dampening the immune system’s response to cancer.
Why Do Most People Quit Ozempic After Two Years? (scientificamerican.com)
The class of weight-loss drugs including semaglutide, sold as Wegovy, have become immensely popular new treatments for obesity. One key factor in their effectiveness is that people need to take them indefinitely—but in practice, many don’t. A recent JAMA Network Open analysis found the vast majority of people quit taking these drugs within two years—such stops in treatment often reverses weight loss and health gains.
The disease-fighting promise of mRNA (phys.org)
In recent years, mRNA technology enabled the rapid development of vaccines to fight COVID-19, saving millions of lives.
What Is Death? (preservinghope.substack.com)
In the past few decades, medical science has rendered obsolete centuries of experience, tradition, and language about our mortality and created a new difficulty for mankind: how to die.
AI-Designed Antivenoms: New Proteins to Block Deadly Snake Toxins (beehiiv.com)
AI-designed proteins can block toxins contained in the venom of cobras and other snakes.
The most famous carbon dioxide absorber (howequipmentworks.com)
Unless you are an anaesthetist, you probably wouldn’t know what a carbon dioxide absorber is (red arrow below).
Political beliefs affect patients' trust in doctors, study finds (news.uoregon.edu)
Adipose tissue retains an epigenetic memory of obesity after weight loss (nature.com)
Reducing body weight to improve metabolic health and related comorbidities is a primary goal in treating obesity1,2.
Childhood obesity requires early, aggressive treatment, new guidelines say (npr.org)
Children with obesity should be offered more intensive treatment options earlier, including therapy and medication, says the leading U.S. pediatricians group.
Five Takeaways from New Research About A.D.H.D (nytimes.com)
As diagnoses of A.D.H.D. and prescriptions for medications hit new record highs, scientists who study the condition are wrestling with some fundamental questions about the way we define and treat it.
AI used for skin cancer checks at London hospital (bbc.com)
An NHS hospital in west London is pioneering the use of Artificial Intelligence (AI) to help check for skin cancer.
Shingles vaccine found to cut dementia risk by 20% (newatlas.com)
Taking advantage of a unique public health policy in the UK, a new study has found that receiving the shingles vaccine reduces dementia risk by 20%.
RNA interference and nanomedicine team up to fight dangerous fungal infections (phys.org)
Ask HN: Biggest non-tech scientific innovations of the 21st century? (ycombinator.com)
The tech industry often dominates headlines here on HN, but what are the major scientific breakthroughs in other fields (biology, medicine, physics, chemistry, climate science, etc...) in the last two decades?
Antiviral chewing gum to reduce influenza and herpes simplex virus transmission (penntoday.upenn.edu)
Researchers at Penn Dental Medicine and collaborators have used a clinical-grade antiviral chewing gum to substantially reduce viral loads of two herpes simplex viruses and two influenza A strains in experimental models.
Origami Nanobot Drug Delivery To Kill Cancer Cells (phys.org)
Maurice Hilleman (wikipedia.org)
Cell Death as a Driving Force in Glioblastoma (feinberg.northwestern.edu)
Cell death has been found to be a driving factor in glioblastoma progression, according to a Northwestern-Medicine-led study published in the Proceedings of the National Academy of Sciences.
A case of humidifier lung; the key diagnosis is detailed medical history taking (nlm.nih.gov)
A 74‐year‐old woman was admitted with a dry cough and dyspnea that had persisted for 2 weeks at the beginning of winter.
Five Nurses who work on the same floor at hospital have brain tumors (nbcnews.com)
A Boston-area hospital is investigating after five nurses who have worked on the same floor have developed brain tumors.
Mitochondria transplants could cure diseases and lengthen lives (economist.com)
Organ transplants are a familiar idea. Organelle transplants, less so. Yet organelles are to cells what organs are to bodies—specialised components that divvy up the labour needed to keep the whole thing ticking over. Swapping old organelles for new in cells where the machinery has switched from ticking to tocking thus makes sense in principle. And, for one type of organelle, that principle is now being tested in practice.
Ethically sourced "spare" human bodies could revolutionize medicine (technologyreview.com)
Human “bodyoids” could reduce animal testing, improve drug development, and alleviate organ shortages.
Some gut bacteria could make certain drugs less effective, study indicates (phys.org)
A study published in Nature Chemistry by researchers from the University of Pittsburgh and Yale University shows how common gut bacteria can metabolize certain oral medications that target cellular receptors called GPCRs, potentially rendering these important drugs less effective.
Pink Skies (ist.ac.at)
Organoids have revolutionized science and medicine, providing platforms for disease modeling, drug testing, and understanding developmental processes. While not exact replicas of human organs, they offer significant insights. The Siegert group at the Institute of Science and Technology Austria (ISTA) presents a new organoid model that reveals details of the developing nervous system’s response to viral infections, such as Rubella. This model could influence pharmaceutical testing, particularly benefiting drug safety for pregnant women.
Mitochondria transplants could cure diseases and lengthen lives (economist.com)
Organ transplants are a familiar idea. Organelle transplants, less so. Yet organelles are to cells what organs are to bodies—specialised components that divvy up the labour needed to keep the whole thing ticking over. Swapping old organelles for new in cells where the machinery has switched from ticking to tocking thus makes sense in principle. And, for one type of organelle, that principle is now being tested in practice.
First Retinal Treatment to Restore Damaged Vision (businesskorea.co.kr)
A research team of the Korea Advanced Institute of Science & Technology (KAIST) has developed the world's first retinal disease treatment that can restore damaged vision.
New blood test checks for Alzheimer's and assesses progression, study (theguardian.com)
Researchers have developed a blood test for patients with thinking and memory problems to check if they have Alzheimer’s and to see how far it has progressed.
A streaming brain-to-voice neuroprosthesis to restore naturalistic communication (nature.com)
Natural spoken communication happens instantaneously.
First map of human brain mitochondria is 'groundbreaking' achievement (nature.com)
Scientists have created the first map of the crucial structures called mitochondria throughout the entire brain ― a feat that could help to unravel age-related brain disorders1.