Hacker News with Generative AI: Medicine

Five Nurses who work on the same floor at hospital have brain tumors (nbcnews.com)
A Boston-area hospital is investigating after five nurses who have worked on the same floor have developed brain tumors.
Mitochondria transplants could cure diseases and lengthen lives (economist.com)
Organ transplants are a familiar idea. Organelle transplants, less so. Yet organelles are to cells what organs are to bodies—specialised components that divvy up the labour needed to keep the whole thing ticking over. Swapping old organelles for new in cells where the machinery has switched from ticking to tocking thus makes sense in principle. And, for one type of organelle, that principle is now being tested in practice.
Ethically sourced "spare" human bodies could revolutionize medicine (technologyreview.com)
Human “bodyoids” could reduce animal testing, improve drug development, and alleviate organ shortages.
Some gut bacteria could make certain drugs less effective, study indicates (phys.org)
A study published in Nature Chemistry by researchers from the University of Pittsburgh and Yale University shows how common gut bacteria can metabolize certain oral medications that target cellular receptors called GPCRs, potentially rendering these important drugs less effective.
Pink Skies (ist.ac.at)
Organoids have revolutionized science and medicine, providing platforms for disease modeling, drug testing, and understanding developmental processes. While not exact replicas of human organs, they offer significant insights. The Siegert group at the Institute of Science and Technology Austria (ISTA) presents a new organoid model that reveals details of the developing nervous system’s response to viral infections, such as Rubella. This model could influence pharmaceutical testing, particularly benefiting drug safety for pregnant women.
Mitochondria transplants could cure diseases and lengthen lives (economist.com)
Organ transplants are a familiar idea. Organelle transplants, less so. Yet organelles are to cells what organs are to bodies—specialised components that divvy up the labour needed to keep the whole thing ticking over. Swapping old organelles for new in cells where the machinery has switched from ticking to tocking thus makes sense in principle. And, for one type of organelle, that principle is now being tested in practice.
First Retinal Treatment to Restore Damaged Vision (businesskorea.co.kr)
A research team of the Korea Advanced Institute of Science & Technology (KAIST) has developed the world's first retinal disease treatment that can restore damaged vision.
New blood test checks for Alzheimer's and assesses progression, study (theguardian.com)
Researchers have developed a blood test for patients with thinking and memory problems to check if they have Alzheimer’s and to see how far it has progressed.
A streaming brain-to-voice neuroprosthesis to restore naturalistic communication (nature.com)
Natural spoken communication happens instantaneously.
First map of human brain mitochondria is 'groundbreaking' achievement (nature.com)
Scientists have created the first map of the crucial structures called mitochondria throughout the entire brain ― a feat that could help to unravel age-related brain disorders1.
Excitable cells (jenevoldsen.com)
I wrote this post to answer some of the questions, I had as a medical student, when I first learned about cardiac arrhythmias. Mainly, what are the conditions required to initiate and maintain a reentrant arrhythmia? That is, a state where the heart muscles are continuously activated by a self-sustaining loop, independent of the normal pace-making system. These arrhythmias can be benign, as with AV-nodal reentry tachycardia (AVNRT); a common, and usually harmless, cause of palpitations in young people.
Medical Benchmarks and the Myth of the Universal Patient (newyorker.com)
When my daughter was ten and a half months old, she qualified as “wasted,” which UNICEF describes as “the most immediate, visible and life-threatening form of malnutrition.”
The Mysterious Flow of Fluid in the Brain (quantamagazine.org)
Encased in the skull, perched atop the spine, the brain has a carefully managed existence. It receives only certain nutrients, filtered through the blood-brain barrier; an elaborate system of protective membranes surrounds it. That privileged space contains a mystery. For more than a century, scientists have wondered: If it’s so hard for anything to get into the brain, how does waste get out?
Good drug news – More important things happening in biotechnology and medicine (worksinprogress.news)
We recently released Issue 18 of Works in Progress. Read about prehistoric psychopaths, fertility on demand and the king of fruits here. Today on Links in Progress Asimov Press’s Niko McCarty and our own Saloni Dattani return to review more important things happening in the world of biotechnology and medicine.
Prostate cancer surgery breakthrough offers hope for erectile function (theguardian.com)
A more precise form of prostate cancer surgery nearly doubles the chances of men retaining erectile function afterwards compared with standard surgery, according to the first comprehensive trial of the procedure.
A Surprise Hair Loss Breakthrough: Sugar Gel Triggers Robust Regrowth (sciencealert.com)
In 2024, scientists stumbled upon a potential new treatment for hereditary-patterned baldness, the most common cause of hair loss in both men and women worldwide.
All Placebos are not created equal (2021) (samstack.io)
All Placebos are not created equal
Long-acting injectable HIV therapy offers hope for those unable to take pills (medicalxpress.com)
Patients who struggle to take daily HIV pills can benefit from long-acting injectable treatments, a new study by researchers at UCSF has found.
Google's AI 'co-scientist' cracked 10-year superbug problem in just 2 days (livescience.com)
Type 2 immunity in allergic diseases (nature.com)
Significant advancements have been made in understanding the cellular and molecular mechanisms of type 2 immunity in allergic diseases such as asthma, allergic rhinitis, chronic rhinosinusitis, eosinophilic esophagitis (EoE), food and drug allergies, and atopic dermatitis (AD).
Hair loss drug finasteride can cause debilitating side-effects, men say (cbc.ca)
For decades, millions of men around the world have turned to a drug — finasteride, or Propecia, its most well-known brand name — to slow hair loss. But an increasing number of experts are sounding the alarm that this medication can cause rare but serious side-effects, which can persist after stopping treatment.
How a Quack TV Doctor Made It to Washington (nytimes.com)
Before medical contrarianism became intrinsic to his identity, Dr. Mehmet Oz appeared motivated by curiosity rather than opportunism.
Metformin-regulated glucose flux from the circulation to the intestinal lumen (nature.com)
Through a retrospective analysis of existing FDG PET-MRI images, we recently demonstrated that metformin increases the accumulation of FDG in the intestinal lumen, suggesting that metformin stimulates glucose excretion into the intestine. However, the details of this phenomenon remain unclear. We here investigate the detailed dynamics of intestinal glucose excretion, including the rate of excretion and the metabolism of excreted glucose, in both the presence and absence of metformin.
Covid-flu vaccine could provide broader immunity and lasting protection (medicalxpress.com)
Cornell researchers have developed a new vaccine platform that could provide more robust, longer-lasting protection from both COVID-19 and influenza, and broader immunity to different flu strains.
Ozempic for Sleep (isaak.net)
This is favorite family in the world — the Johnsons from Utah.
The Ozempocalypse Is Nigh (astralcodexten.com)
Three GLP-1 drugs are approved for weight loss in the United States:
New anti-obesity drugs outperform Ozempic (elpais.com)
For decades, people who are overweight have been given simple advice: move more and eat less. However, in more than 80% of cases, this approach only works in the short term.
Aspirin prevents metastasis by limiting platelet TXA2 suppression of immunity (nature.com)
Metastasis is the spread of cancer cells from primary tumours to distant organs and is the cause of 90% of cancer deaths globally1,2.
Boosting mitochondrial health to counteract neurodegeneration (sciencedirect.com)
Stanford scientists discover new Ozempic alternative with RegEx (twitter.com)
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