Hacker News with Generative AI: Medicine

Microbe that infests hospitals can digest medical-grade plastic ― a first (nature.com)
A strain of bacterium that often causes infections in hospital can break down plastic, research published this week in Cell Reports reveals1.
Will protein design tools solve the snake antivenom shortage? (owlposting.com)
There has been a fair bit of discussion over this recent ‘creating binders against snake venom protein’ paper from the Baker Lab that came out earlier this year, including this article from Derek Lowe.
Protein-slayer drugs could beat some of the cruellest cancers (nature.com)
Momentum is building for PROTAC treatments that eliminate disease-causing proteins, including those responsible for difficult-to-treat childhood cancers.
The next superbug threat is already here. It's going to be harder to overcome (cnn.com)
New studies offer insight into Lyme disease’s treatment, lingering symptoms (news.northwestern.edu)
Northwestern scientists have identified an antibiotic that cures Lyme disease at a fraction of the dosage of the current “gold standard” treatment and discovered what may cause a treated infection to mimic chronic illness in patients.
Psilocybin reduced depression symptoms as much as leading antidepressant (2021) (massivesci.com)
Scientists May Have Found a Natural Alternative to Ozempic (sciencealert.com)
Scientists may have identified a way to naturally regulate blood sugar levels and sugar cravings in a similar fashion to drugs like Ozempic.
Blocking surprising master regulator of immunity eradicates liver tumors in mice (med.stanford.edu)
A protein identified nearly 40 years ago for its ability to stimulate the production of red blood cells plays a surprising, critical role in dampening the immune system’s response to cancer.
Universal Antivenom May Grow Out of Man Who Let Snakes Bite Him 100s of Times (nytimes.com)
Scientists identified antibodies that neutralized the poison in whole or in part from the bites of cobras, mambas and other deadly species.
Snake collector's immunity quest opens path towards universal antivenom (theguardian.com)
Blood from man bitten hundreds of times by deadly species is used to create most broadly protective antivenom yet
The antibiotic that takes the bite out of Lyme (news.northwestern.edu)
Scientists from Northwestern University have identified that piperacillin, an antibiotic in the same class as penicillin, effectively cured mice of Lyme disease at 100-times less than the effective dose of doxycycline, the current gold standard treatment.
Medicine Spares Cancer Patients from Grisly Surgeries and Harsh Therapies (nytimes.com)
For a limited group of cancer patients who have solid tumors in the stomach, rectum, esophagus and other organs, an immunotherapy trial offered stunning results.
Albert Stevens, the most radioactive man (wikipedia.org)
Albert Stevens (1887–1966), also known as patient CAL-1 and most radioactive human ever, was a house painter from Ohio who was subjected to an involuntary human radiation experiment and survived the highest known accumulated radiation dose in any human.
Home washing machines fail to remove important pathogens from textiles (medicalxpress.com)
Health care workers who wash their uniforms at home may be unknowingly contributing to the spread of antibiotic-resistant infections in hospitals, according to a new study led by Katie Laird of De Montfort University, published in PLOS One.
Metagenomics test saves woman's sight after mystery infection (bbc.co.uk)
A 29-year-old doctor from Bristol has had her eyesight saved after a "game-changing" test identified a mystery infection that had plagued her health for five years.
The end of the 'Golden Hour' and the transformation of U.S. combat medicine (taskandpurpose.com)
During the post-9/11 wars, the US military came as close to perfecting near-immediate trauma care on the battlefield as the chaos of combat would allow.
Ask HN: What Is the Hacker News for Medicine? (ycombinator.com)
Specifically in regards to interesting research, breakthrough, or even tidbits about medicine & human body.
An end to all this prostate trouble? (yarchive.net)
The prostate gland causes entirely too many problems. In the US, prostate cancer kills about one man of every forty. “Benign prostate hyperplasia” (BPH) is even more common, affecting most men over age 60. It pinches the urinary tract, making it hard to urinate, and is constantly in danger of transforming from “benign” to “malignant”.
Sham Surgery (wikipedia.org)
Sham surgery (or placebo surgery) is a faked surgical intervention that omits the step thought to be therapeutically necessary.
'Vaguely Threatening': Federal Prosecutor Queries Leading Medical Journal (nytimes.com)
A federal prosecutor in Washington has contacted The New England Journal of Medicine, considered the world’s most prestigious medical journal, with questions that suggested without evidence that it was biased against certain views and influenced by external pressures.
Blocking a master regulator of immunity eradicates liver tumors in mice (med.stanford.edu)
A protein identified nearly 40 years ago for its ability to stimulate the production of red blood cells plays a surprising, critical role in dampening the immune system’s response to cancer.
Why Do Most People Quit Ozempic After Two Years? (scientificamerican.com)
The class of weight-loss drugs including semaglutide, sold as Wegovy, have become immensely popular new treatments for obesity. One key factor in their effectiveness is that people need to take them indefinitely—but in practice, many don’t. A recent JAMA Network Open analysis found the vast majority of people quit taking these drugs within two years—such stops in treatment often reverses weight loss and health gains.
The disease-fighting promise of mRNA (phys.org)
In recent years, mRNA technology enabled the rapid development of vaccines to fight COVID-19, saving millions of lives.
What Is Death? (preservinghope.substack.com)
In the past few decades, medical science has rendered obsolete centuries of experience, tradition, and language about our mortality and created a new difficulty for mankind: how to die.
AI-Designed Antivenoms: New Proteins to Block Deadly Snake Toxins (beehiiv.com)
AI-designed proteins can block toxins contained in the venom of cobras and other snakes.
The most famous carbon dioxide absorber (howequipmentworks.com)
Unless you are an anaesthetist, you probably wouldn’t know what a carbon dioxide absorber is (red arrow below).
Political beliefs affect patients' trust in doctors, study finds (news.uoregon.edu)
Adipose tissue retains an epigenetic memory of obesity after weight loss (nature.com)
Reducing body weight to improve metabolic health and related comorbidities is a primary goal in treating obesity1,2.
Childhood obesity requires early, aggressive treatment, new guidelines say (npr.org)
Children with obesity should be offered more intensive treatment options earlier, including therapy and medication, says the leading U.S. pediatricians group.
Five Takeaways from New Research About A.D.H.D (nytimes.com)
As diagnoses of A.D.H.D. and prescriptions for medications hit new record highs, scientists who study the condition are wrestling with some fundamental questions about the way we define and treat it.