Hacker News with Generative AI: Clinical Trials

Stem cells head to the clinic: treatments for cancer, diabetes and Parkinson's (nature.com)
More than 100 clinical trials put stem cells for regenerative medicine to the test. It’s a turning point for a field beset with ethical and political controversy.

Stem Cells, Medicine, Healthcare, Clinical Trials, Ethical Issues

13 points by LinuxBender 27 days ago | 1 comments

The case for clinical trial abundance (ifp.org)
In 2014, the first SGLT2 inhibitor, dapagliflozin, was approved for patients with Type II diabetes for the control of blood glucose levels. Since then, the list of indications for this class of molecules has expanded to include kidney disease (2021) and heart failure (2020) in non-diabetics, both important sources of morbidity and mortality. Despite being an already developed drug with safety data, these repurposings took seven and six years, respectively.

Clinical Trials, Medical Research, Diabetes, Cardiovascular Health, Drug Repurposing

52 points by apsec112 30 days ago | 5 comments

Promising early data in triple negative breast cancer (statnews.com)
New data suggests researchers may have found one of their most promising candidates yet for the next generation in immunotherapy drugs — bispecific antibodies targeting two key proteins in cancer, PD1 or PD-L1 and VEGF.A small early trial on one such bispecific compound was presented by researchers working with BioNTech at the San Antonio Breast Cancer Symposium on Tuesday. The bispecific compound, called BNT-327, had positive results in patients with triple negative breast cancer.

Cancer, Immunotherapy, Drugs, Clinical Trials

10 points by doener 38 days ago | 1 comments

Progress and prospects of mRNA-based drugs in pre-clinical/clinical applications (nature.com)
In the last decade, messenger ribonucleic acid (mRNA)-based drugs have gained great interest in both immunotherapy and non-immunogenic applications.

mRNA Technology, Biomedicine, Drug Development, Clinical Trials, Medical Research

3 points by lawrenceyan 60 days ago | 0 comments

Psilocybin bests SSRI for major depression in first long-term comparison (medscape.com)

Psilocybin, Depression, Mental Health, Pharmaceuticals, Clinical Trials

582 points by Thomvis 98 days ago | 379 comments

Rwanda to receive experimental vaccines to combat Marburg outbreak (statnews.com)
Experimental vaccines and therapeutics to combat the deadly Marburg virus will begin arriving this weekend in Rwanda, where they will be used in clinical trials expected to begin soon, a U.S. government official confirmed on Friday.

Vaccines, Public Health, Africa, Viral Outbreaks, Clinical Trials

4 points by geox 105 days ago | 0 comments

mRNA cancer vaccine shows potential for advanced stage cancer patients (kcl.ac.uk)
Interim data from the Phase I dose escalation part of the mRNA cancer immunotherapy (mRNA-4359), show promise in patients with advanced solid cancers.

Cancer, Vaccines, Clinical Trials, Immunotherapy

13 points by nopakos 123 days ago | 0 comments

Gilead's twiceyearly shot cut HIV infections by 96% in trial (cnbc.com)

HIV, Medicine, Health, Clinical Trials

4 points by jackallis 128 days ago | 0 comments

Epilepsy drug shows promise in reducing obstructive sleep apnea symptoms (ajmc.com)
Sulthiame, an epilepsy drug sold under the brand name Ospolot in Europe, appeared to reduce symptoms of obstructive sleep apnea (OSA) in a late-breaking clinical trial presented at the European Respiratory Society (ERS) Congress 2024.

Medicine, Sleep Disorders, Clinical Trials, Epilepsy

7 points by geox 130 days ago | 0 comments

World-first lung cancer vaccine trials launched across seven countries (theguardian.com)

Lung Cancer, Medical Research, Vaccines, Clinical Trials

29 points by doener 139 days ago | 1 comments

World-first mRNA lung cancer vaccine trials launched in seven countries (theguardian.com)

Cancer, Healthcare, Science, Clinical Trials, Vaccines

12 points by NKosmatos 148 days ago | 0 comments

New HIV Prevention Drug Shows 100% Efficacy in Clinical Trial (sciencealert.com)

HIV, Medicine, Health, Clinical Trials

37 points by doener 187 days ago | 2 comments

Gilead shot prevents all HIV cases in trial (bloomberg.com)