Hacker News with Generative AI: Clinical Trials

Clinical trial: novel nutritional formula treats gut microbial overgrowth (medicalxpress.com)
Cedars-Sinai researchers have developed a novel nutritional formula, mBiota Elemental, a palatable elemental diet (PED) that reduces the abundance of key gut microbiome taxa and improves symptoms in patients with small intestinal bacterial overgrowth (SIBO) and intestinal methanogen overgrowth (IMO).

Clinical Trials, Gut Health, Nutrition, Medical Research

64 points by wglb 2 days ago | 25 comments

Phase I/II trial of iPS-cell-derived dopaminergic cells for Parkinson's disease (nature.com)
Parkinson’s disease is caused by the loss of dopamine neurons, causing motor symptoms.

Medical Research, Parkinson's Disease, Clinical Trials

28 points by LinuxBender 8 days ago | 0 comments

4:3 Intermittent fasting shows greater weight loss than caloric restriction (medicalxpress.com)
A randomized clinical trial compared the effects of 4:3 intermittent fasting versus daily caloric restriction on weight loss when combined with comprehensive behavioral support in adults with overweight or obesity.

Health, Nutrition, Weight Loss, Clinical Trials, Intermittent Fasting

18 points by PaulHoule 19 days ago | 3 comments

Therapy chatbot trial yields mental health benefits (home.dartmouth.edu)
Dartmouth researchers conducted the first-ever clinical trial of a generative AI-powered therapy chatbot and found that the software resulted in significant improvements in participants’ symptoms, according to results published March 27 in NEJM AI.

Mental Health, Artificial Intelligence, Chatbots, Clinical Trials

14 points by geox 28 days ago | 4 comments

World-first experimental cancer treatment paves way for clinical trial (wehi.edu.au)
An experimental treatment for an aggressive and lethal brain cancer has today been published in Nature Medicine, paving the way for a clinical trial to be conducted by researchers at The Brain Cancer Centre.

Cancer Treatment, Medical Research, Clinical Trials

209 points by femto 57 days ago | 78 comments

mRNA Vaccine Shows Sustained Immune Response in Small Pancreatic Cancer Trial (mskcc.org)
An experimental approach to treating pancreatic cancer with the messenger RNA (mRNA)-based therapeutic cancer vaccine autogene cevumeran continues to show potential to stimulate an immune response that may reduce the risk of the disease returning after surgery in a small patient group.

Cancer Treatment, mRNA Vaccines, Clinical Trials

14 points by greesil 59 days ago | 0 comments

Abandoned in the Middle of Clinical Trials, Because of a Trump Order (nytimes.com)
The stop-work order on U.S.A.I.D.-funded research has left thousands of people with experimental drugs and devices in their bodies, with no access to monitoring or care.

Clinical Trials, Medical Research, Trump Administration, Health Policy, Government Regulations

29 points by perihelions 78 days ago | 0 comments

Clinical Trials Are Drowning in Data but Starving for Patients (seangeiger.substack.com)
The first clinical trial happened on a damp naval ship in 1747. James Lind, a Scottish naval surgeon, divided twelve scurvy-stricken sailors into pairs to test different treatments: oranges and lemons, cider, vinegar, sulfuric acid, garlic paste, and seawater.

Clinical Trials, Health, Data Science

7 points by benjaminmaccini 79 days ago | 0 comments

Spinal cord electrical stimulation restores neural function in clinical trial (medicalxpress.com)
A new drug-free, minimally invasive intervention targets the root cause of progressive loss of neural function in spinal muscle atrophy (SMA), an inherited neuromuscular disease.

Medical Research, Neurology, Clinical Trials

10 points by mhb 79 days ago | 0 comments

Stem cells head to the clinic: treatments for cancer, diabetes and Parkinson's (nature.com)
More than 100 clinical trials put stem cells for regenerative medicine to the test. It’s a turning point for a field beset with ethical and political controversy.

Stem Cells, Medicine, Healthcare, Clinical Trials, Ethical Issues

13 points by LinuxBender 125 days ago | 1 comments

The case for clinical trial abundance (ifp.org)
In 2014, the first SGLT2 inhibitor, dapagliflozin, was approved for patients with Type II diabetes for the control of blood glucose levels. Since then, the list of indications for this class of molecules has expanded to include kidney disease (2021) and heart failure (2020) in non-diabetics, both important sources of morbidity and mortality. Despite being an already developed drug with safety data, these repurposings took seven and six years, respectively.

Clinical Trials, Medical Research, Diabetes, Cardiovascular Health, Drug Repurposing

52 points by apsec112 128 days ago | 5 comments

Promising early data in triple negative breast cancer (statnews.com)
New data suggests researchers may have found one of their most promising candidates yet for the next generation in immunotherapy drugs — bispecific antibodies targeting two key proteins in cancer, PD1 or PD-L1 and VEGF.A small early trial on one such bispecific compound was presented by researchers working with BioNTech at the San Antonio Breast Cancer Symposium on Tuesday. The bispecific compound, called BNT-327, had positive results in patients with triple negative breast cancer.

Cancer, Immunotherapy, Drugs, Clinical Trials

10 points by doener 136 days ago | 1 comments

Progress and prospects of mRNA-based drugs in pre-clinical/clinical applications (nature.com)
In the last decade, messenger ribonucleic acid (mRNA)-based drugs have gained great interest in both immunotherapy and non-immunogenic applications.

mRNA Technology, Biomedicine, Drug Development, Clinical Trials, Medical Research

3 points by lawrenceyan 159 days ago | 0 comments

Psilocybin bests SSRI for major depression in first long-term comparison (medscape.com)

Psilocybin, Depression, Mental Health, Pharmaceuticals, Clinical Trials

582 points by Thomvis 196 days ago | 379 comments

Rwanda to receive experimental vaccines to combat Marburg outbreak (statnews.com)
Experimental vaccines and therapeutics to combat the deadly Marburg virus will begin arriving this weekend in Rwanda, where they will be used in clinical trials expected to begin soon, a U.S. government official confirmed on Friday.

Vaccines, Public Health, Africa, Viral Outbreaks, Clinical Trials

4 points by geox 203 days ago | 0 comments

mRNA cancer vaccine shows potential for advanced stage cancer patients (kcl.ac.uk)
Interim data from the Phase I dose escalation part of the mRNA cancer immunotherapy (mRNA-4359), show promise in patients with advanced solid cancers.

Cancer, Vaccines, Clinical Trials, Immunotherapy

13 points by nopakos 221 days ago | 0 comments

Gilead's twiceyearly shot cut HIV infections by 96% in trial (cnbc.com)

HIV, Medicine, Health, Clinical Trials

4 points by jackallis 226 days ago | 0 comments

Epilepsy drug shows promise in reducing obstructive sleep apnea symptoms (ajmc.com)
Sulthiame, an epilepsy drug sold under the brand name Ospolot in Europe, appeared to reduce symptoms of obstructive sleep apnea (OSA) in a late-breaking clinical trial presented at the European Respiratory Society (ERS) Congress 2024.

Medicine, Sleep Disorders, Clinical Trials, Epilepsy

7 points by geox 228 days ago | 0 comments

World-first lung cancer vaccine trials launched across seven countries (theguardian.com)

Lung Cancer, Medical Research, Vaccines, Clinical Trials

29 points by doener 237 days ago | 1 comments

World-first mRNA lung cancer vaccine trials launched in seven countries (theguardian.com)

Cancer, Healthcare, Science, Clinical Trials, Vaccines

12 points by NKosmatos 246 days ago | 0 comments

New HIV Prevention Drug Shows 100% Efficacy in Clinical Trial (sciencealert.com)

HIV, Medicine, Health, Clinical Trials

37 points by doener 285 days ago | 2 comments

Gilead shot prevents all HIV cases in trial (bloomberg.com)