Hacker News with Generative AI: Drugs

An 'uncensored' dark web AI is offering step-by-step guides on how to make meth (dailydot.com)
An anonymous developer launched an artificial intelligence (AI) chatbot on the dark web in an effort to provide “uncensored” access to information.
'Barbarians' May Have Been Inspired by Opium When Attacking Rome, Study Suggests (haaretz.com)
The Romans thought the barbarian monsters on their borders should settle for alcohol, but the drug spoons the Germanic warriors carried into battle suggest they didn't agree
Fentanyl Almost Killed Michael Brewer. Now He Wants Snap to Pay (bloomberg.com)
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Promising early data in triple negative breast cancer (statnews.com)
New data suggests researchers may have found one of their most promising candidates yet for the next generation in immunotherapy drugs — bispecific antibodies targeting two key proteins in cancer, PD1 or PD-L1 and VEGF.A small early trial on one such bispecific compound was presented by researchers working with BioNTech at the San Antonio Breast Cancer Symposium on Tuesday. The bispecific compound, called BNT-327, had positive results in patients with triple negative breast cancer.
Russia's Dead Drop Drug Revolution (globalinitiative.net)
There has been a groundbreaking shift in the global drug trade, pioneered in Russia and now spreading globally.
Weight-loss drug found to shrink muscle in mice, human cells (ualberta.ca)
Trendy weight-loss drugs making headlines for shrinking waistlines may also be shrinking the human heart and other muscles, according to a new University of Alberta study whose authors say should serve as a “cautionary tale” about possible long-term health effects of these drugs.
GLP-1s are among the most important drug breakthroughs (economist.com)
IN THE HISTORY of medicine, a few drugs tower above all others. Humira for rheumatoid arthritis; Prozac for depression; statins to prevent heart disease and strokes. All have helped patients far beyond doctors’ initial expectations and continue to benefit millions of people every day. A new class of drugs is set to join their ranks and has the potential to eclipse them all—GLP-1 receptor agonists.
Psychedelic Mushrooms Are Getting Much, Much Stronger (wired.com)
Cultivators are turning to genetic sequencing and cellular-manipulation techniques to breed highly potent mushrooms—leaving some unprepared psychonauts in distress.
On 17th century "cocaine" (resobscura.substack.com)
Earlier this year, amid a sea of bones in the vaulted crypt beneath Milan’s Ca’ Granda hospital, Italian researchers made an intriguing discovery. Analyzing mummified brain tissue from two men who died at the hospital in the seventeenth century, they found evidence of coca use—the earliest ever detected outside of South America.
Science Says Everything You Know about Food, Diet and Drugs Is Wrong (newsweek.com)
Science can't provide definitive answers.
Scientists Discover 17th Century Bones Contained Cocaine (popularmechanics.com)
The surprising discovery reveals Europeans sniffed around much earlier than we thought.
Forensic toxicology backdates the use of coca plant in Europe to the early 1600s (sciencedirect.com)
From Opium to Saffron, the Ancients Knew a Thing or Two About Drugs (thenation.com)
HIV drug could be made for just $40 a year for every patient (theguardian.com)
If Fever Helps Fight Infection, Should I Avoid Fever-Reducing Drugs? (2018) (nytimes.com)
Meta allows drug ads selling everything from opioids to cocaine (techtransparencyproject.org)
I Wasn't the First Person to Find the NJ Coca-Cola Cocaine Factory (2016) (medium.com)
Meta has run hundreds of ads for cocaine, opioids and other drugs (wsj.com)
Cocaine found in muscle/liver of sharpnose sharks off coast of Rio de Janeiro (phys.org)
We bought everything needed to make $3M worth of fentanyl (reuters.com)
MPPP – The first 'designer drug' disaster (2023) (bris.ac.uk)
Sharks test positive for cocaine in waters off Brazilian coast (thetimes.com)
A scientist took a psychedelic drug – and watched his own brain 'fall apart' (npr.org)
Mexico may legalize magic mushrooms (latimes.com)
Synthetic psychedelic found in candies linked to seizures, intubation (arstechnica.com)
Tripping on Xenon Gas (2023) (tripsitter.substack.com)
Bugs, drugs and electric venom: is this the most deadly library in the world? (theguardian.com)
FDA Panel rejects MDMA as a PTSD treatment in possible setback for advocates (apnews.com)
Ask HN: Have you tried weight loss drugs? (ycombinator.com)
Outlaw chemists used 'blotter' to dose the world with LSD Essays (aeon.co)