Hacker News with Generative AI: Weight Loss

Newfound Mechanism Rewires Cellular Energy Processing for Drastic Weight Loss (nyulangone.org)
Mice genetically engineered to lack the ability to make the amino acid cysteine, and fed a cysteine-free diet, lost 30 percent of their body weight in just one week, a new study shows.
Genetics, Weight Loss, Metabolic Research, Cellular Biology
15 points by gnabgib 2 days ago | 5 comments
People who stop weight loss drugs return to original weight within year (theguardian.com)
People on weight loss drugs regain all the weight they have lost within a year of stopping the medication, analysis has shown.
Health, Weight Loss, Medicine, Research
10 points by neaden 9 days ago | 2 comments
WeightWatchers Files for Bankruptcy (abc7.com)
New York -- WeightWatchers, the 62-year-old program that revolutionized dieting for millions of people around the world, has filed for bankruptcy.
Business, Bankruptcy, Weight Loss
17 points by lxm 17 days ago | 4 comments
Why Do Most People Quit Ozempic After Two Years? (scientificamerican.com)
The class of weight-loss drugs including semaglutide, sold as Wegovy, have become immensely popular new treatments for obesity. One key factor in their effectiveness is that people need to take them indefinitely—but in practice, many don’t. A recent JAMA Network Open analysis found the vast majority of people quit taking these drugs within two years—such stops in treatment often reverses weight loss and health gains.
Obesity, Medicine, Healthcare, Weight Loss, Drugs
11 points by paulpauper 30 days ago | 1 comments
Daily Pill May Work as Well as Ozempic for Weight Loss and Blood Sugar (nytimes.com)
A daily pill may be as effective in lowering blood sugar and aiding weight loss in people with Type 2 diabetes as the popular injectable drugs Mounjaro and Ozempic, according to results of a clinical trial announced by Eli Lilly on Thursday morning.
Health, Diabetes, Weight Loss, Pharmaceuticals
32 points by uxhacker 36 days ago | 71 comments
4:3 Intermittent fasting shows greater weight loss than caloric restriction (medicalxpress.com)
A randomized clinical trial compared the effects of 4:3 intermittent fasting versus daily caloric restriction on weight loss when combined with comprehensive behavioral support in adults with overweight or obesity.
Health, Nutrition, Weight Loss, Clinical Trials, Intermittent Fasting
18 points by PaulHoule 46 days ago | 3 comments
Eli Lilly will soon release key data on its weight loss pill orforglipron (cnbc.com)
Pharmaceuticals, Weight Loss, Healthcare, Eli Lilly
32 points by toomuchtodo 60 days ago | 29 comments
Ozempic for Sleep (isaak.net)
This is favorite family in the world — the Johnsons from Utah.
Health, Weight Loss, Medicine
84 points by zdw 69 days ago | 18 comments
The Ozempocalypse Is Nigh (astralcodexten.com)
Three GLP-1 drugs are approved for weight loss in the United States:
Medicine, Health, Weight Loss
89 points by impish9208 70 days ago | 94 comments
The Ozempocalypse Is Nigh (astralcodexten.com)
Three GLP-1 drugs are approved for weight loss in the United States:
Pharmaceuticals, Health, Weight Loss
15 points by feross 73 days ago | 5 comments
Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects (medicalxpress.com)
A naturally occurring molecule identified by Stanford Medicine researchers appears similar to semaglutide—also known as Ozempic—in suppressing appetite and reducing body weight.
Medicine, Health, Weight Loss, Pharmaceuticals, Science
423 points by pseudolus 77 days ago | 381 comments
GLP-1 drugs: An economic disruptor? (2024) (wildfirelabs.substack.com)
In 2021, Lisa Chen, a software engineer, started a new weight-loss medication. Then, something interesting happened at her local coffee shop, her employer's healthcare costs, and the global economy.
Healthcare, Economics, Pharmaceuticals, Weight Loss
385 points by herbertl 83 days ago | 531 comments
The Physicians Are Healing Themselves, with Ozempic (nytimes.com)
At cardiology conferences and diabetes meetings, doctors can’t help noticing that thin seems to be very in.
Health, Medicine, Obesity, Weight Loss, Pharmaceuticals
43 points by CharlesW 102 days ago | 86 comments
Can Dieting Lead to Long-Term Weight Loss? (nytimes.com)
Dieting has long been viewed as the path to smaller bodies and better health. Stick to the right diet, the $75 billion U.S. weight loss industry may have you think, and you, too, can lose weight and keep it off.
Weight Loss, Health, Diet, Nutrition
5 points by paulpauper 105 days ago | 0 comments
You've Lost Weight Taking New Obesity Drugs. What Happens If You Stop? (nytimes.com)
Many patients are eager to discontinue Wegovy or Zepbound when their weight loss plateaus. But doctors say it’s difficult to go cold turkey.
Obesity, Weight Loss, Health, Medicine, Science
7 points by paulpauper 109 days ago | 0 comments
Weight-loss surgery down 25 percent as anti-obesity drug use soars (2024) (news.harvard.edu)
A new study examining a large sample of privately insured patients with obesity found that use of drugs such as Ozempic and Wegovy as anti-obesity medications more than doubled from 2022 to 2023. During that same period, there was a 25.6 percent decrease in patients undergoing metabolic bariatric surgery to treat obesity.
Weight Loss, Medical Treatments, Pharmaceuticals, Healthcare, Obesity
7 points by paulpauper 115 days ago | 1 comments
Weight-loss jabs linked to reduced risk of 42 conditions including dementia (theguardian.com)
People with diabetes taking medications found in weight-loss jabs have a reduced risk of 42 conditions, research has found, paving the way for such drugs being used to treat a host of health problems.
Health, Diabetes, Weight Loss, Medical Research
3 points by sandebert 123 days ago | 0 comments
Intermittent fasting is effective for weight loss and improves cardio health (sciencedaily.com)
A team of scientists led by the University of Granada (UGR), the Public University of Navarra (UPNA) and the CIBER has shown that intermittent fasting (reducing the number of hours of intake and extending the hours of fasting each day) is an effective method for losing weight and improves cardiovascular health in people with obesity problems.
Health, Weight Loss, Science, Intermittent Fasting
5 points by iamhamm 134 days ago | 0 comments
The benefits of Ozempic and its kin may extend far beyond weight loss (sciencenews.org)
This year, the popularity of the diabetes and weight-loss drug semaglutide has continued to surge. You’ve probably seen ads on social media or heard from friends who’ve tried top-selling brand-name versions, Ozempic and the higher-dose variety Wegovy (SN: 6/29/24, p. 5), or read accounts of people microdosing these drugs.
Medicine, Weight Loss, Health, Pharmaceuticals
5 points by sohkamyung 161 days ago | 0 comments
Weight loss drugs may also treat addiction, Alzheimer's, and heart disease (arstechnica.com)
Pharmaceutical companies are already cashing in on their other health benefits.
Pharmaceuticals, Health, Weight Loss, Addiction, Alzheimer's
12 points by thehoff 162 days ago | 1 comments
Fat Cells Remember Obesity, Driving the Yo-Yo Effect (technologynetworks.com)
Researchers uncover how epigenetic memory in fat cells drives the yo-yo effect, making weight regain more likely.
Obesity, Health, Genetics, Epigenetics, Weight Loss
5 points by gmays 179 days ago | 1 comments
Fat cells have a memory of obesity – hinting at why it's hard to keep weight off (nature.com)
Even after drastic weight loss, the body’s fat cells carry the ‘memory’ of obesity, research1 shows — a finding that might help to explain why it can be hard to stay trim after a weight-loss programme.
Obesity, Weight Loss, Biology, Health, Science
8 points by SirLJ 180 days ago | 0 comments
Weight-loss drug found to shrink muscle in mice, human cells (ualberta.ca)
Trendy weight-loss drugs making headlines for shrinking waistlines may also be shrinking the human heart and other muscles, according to a new University of Alberta study whose authors say should serve as a “cautionary tale” about possible long-term health effects of these drugs.
Health, Science, Medicine, Weight Loss, Drugs
372 points by Eumenes 184 days ago | 445 comments
Ozempic Could Prevent Diabetes. Should It Be Used for That? (nytimes.com)
New research shows that weight loss medications can stop the progression of prediabetes. Experts don’t all agree on such a use for the drugs.
Diabetes, Medicine, Health, Weight Loss
6 points by bookofjoe 184 days ago | 3 comments
As Ozempic turns consumers off processed foods, junk food industry fights back (nytimes.com)
As revolutionary new weight-loss drugs turn consumers off ultraprocessed foods, the industry is on the hunt for new products.
Health, Food Industry, Weight Loss, Consumer Behavior
27 points by 2four2 185 days ago | 48 comments
Fat cells have 'memory' of obesity – hinting at why it's hard to keep weight off (nature.com)
Even after drastic weight loss, the body’s fat cells carry the ‘memory’ of obesity, research1 shows — a finding that might help to explain why it can be hard to stay trim after a weight-loss programme.
Obesity, Biology, Health, Weight Loss
12 points by bookofjoe 185 days ago | 0 comments
A new stronger Ozempic is coming. Here's what to know (qz.com)
Novo Nordisk (NVO-4.34%) teased some new details about a potential Ozempic successor during a call with investors Tuesday.
Pharmaceuticals, Health, Diabetes, Weight Loss, Business
16 points by toomuchtodo 198 days ago | 3 comments
Weight-loss surgery down 25 percent as anti-obesity drug use soars (news.harvard.edu)
A new study examining a large sample of privately insured patients with obesity found that use of drugs such as Ozempic and Wegovy as anti-obesity medications more than doubled from 2022 to 2023.
Obesity, Healthcare, Pharmaceuticals, Weight Loss
11 points by paulpauper 206 days ago | 1 comments
Exercise Paradox (wikipedia.org)
The exercise paradox,[1] also known as the workout paradox,[2] refers to the finding that physical activity, while essential for maintaining overall health, does not necessarily lead to significant weight loss or increased calorie expenditure.[3] This paradox challenges the common belief that more exercise equates to more calories burned and consequently, more weight loss.[4]
Exercise, Health, Weight Loss, Paradox
54 points by thunderbong 207 days ago | 63 comments
New study finds obesity operations dropped 25.6% in 2023 due to GLP-1 drugs (statnews.com)
For people with obesity, surgeries that shrink, reshape, or otherwise alter the anatomy of the stomach have long reigned supreme as the surest way to weight loss. But in the last few years, with the approval of GLP-1 drugs like Wegovy and Zepbound, more and more people are opting for obesity medicines over gold-standard surgical treatments.
Obesity, Healthcare, Medicine, Pharmaceuticals, Weight Loss
6 points by ck2 208 days ago | 3 comments