Daily Pill May Work as Well as Ozempic for Weight Loss and Blood Sugar(nytimes.com) A daily pill may be as effective in lowering blood sugar and aiding weight loss in people with Type 2 diabetes as the popular injectable drugs Mounjaro and Ozempic, according to results of a clinical trial announced by Eli Lilly on Thursday morning.
Alzheimer's Disease as Type 3 Diabetes(gethealthspan.com) Over the past several decades, Alzheimer’s disease (AD) has been predominantly explained through the lens of amyloid-beta plaques and neurofibrillary tangles, yet an emerging paradigm shift increasingly recognizes metabolic dysfunction—specifically, insulin resistance—as a key driver of AD.
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The case for clinical trial abundance(ifp.org) In 2014, the first SGLT2 inhibitor, dapagliflozin, was approved for patients with Type II diabetes for the control of blood glucose levels. Since then, the list of indications for this class of molecules has expanded to include kidney disease (2021) and heart failure (2020) in non-diabetics, both important sources of morbidity and mortality. Despite being an already developed drug with safety data, these repurposings took seven and six years, respectively.
What is metformin's secret sauce?(news.northwestern.edu) A new Northwestern Medicine study has provided direct evidence in mice that the drug reversibly cuts the cell’s energy supply by interfering with mitochondria, often referred to as the cell’s “powerhouse,” to lower glucose levels.
Ozempic increases risk of debilitating eye condition: studies(sdu.dk) Two independent studies from the University of Southern Denmark (SDU) show that patients with type 2 diabetes who are treated with the drug Ozempic have an increased risk of developing damage to the optic nerve of the eye, which can lead to severe and permanent loss of vision.
Diabetes risk soars for adults who had a sweet tooth as kids(nature.com) It’s tough news to hear on Halloween: a sugary diet in the first two years of life is linked to a higher risk of diabetes and high blood pressure decades later, according to an analysis of UK sugar rationing in the 1950s.
'Smart' insulin prevents diabetic highs – and deadly lows(nature.com) Scientists have designed a new form of insulin that can automatically switch itself on and off depending on glucose levels in the blood. In animals, this ‘smart’ insulin1 reduced high blood-sugar concentrations effectively while preventing levels from dropping too low.
Covid-19 linked to type 2 diabetes onset in children(medicalxpress.com) Pediatric patients aged 10 to 19 years old diagnosed with COVID-19 have a higher risk of new-onset type 2 diabetes within six months compared to those diagnosed with other respiratory infections, according to researchers at Case Western Reserve University School of Medicine.
Stem cells reverse woman’s diabetes(nature.com) A 25-year-old woman with type 1 diabetes started producing her own insulin less than three months after receiving a transplant of reprogrammed stem cells1.