Hacker News with Generative AI: Medical Research

Researchers reveal why the lung is a frequent site of cancer metastasis (medicalxpress.com)
More than half of cancer patients in whom the cancer spreads beyond the primary site have lung metastases. What makes the lungs such a tempting place for cancer cells?
Cancer, Lung Cancer, Medical Research, Metastasis
6 points by pseudolus 16 days ago | 1 comments
Pfizer Stopped Us from Getting Ozempic Decades Ago (nytimes.com)
They called 2023 the year of Ozempic, but it now seems GLP-1 drugs might define an entire decade — or an even longer era.
Pharmaceuticals, Health, Obesity, Medical Research
15 points by bko 22 days ago | 2 comments
A Woman with a Rare Gene Mutation Fights to Avoid Her Mother's Fate (nytimes.com)
A mutant gene is coming to steal Linde Jacobs’s mind. Can she find a way to stop it?
Genetics, Health, Science, Medical Research
9 points by gmays 23 days ago | 1 comments
Hair Loss Breakthrough: A Sugar Gel Triggers Robust Regrowth (sciencealert.com)
Earlier this year, scientists stumbled upon a potential new treatment for hereditary-patterned baldness, the most common cause of hair loss in both men and women worldwide.
Hair Loss, Medical Research, Biology, Treatment
7 points by hilux 28 days ago | 8 comments
The case for clinical trial abundance (ifp.org)
In 2014, the first SGLT2 inhibitor, dapagliflozin, was approved for patients with Type II diabetes for the control of blood glucose levels. Since then, the list of indications for this class of molecules has expanded to include kidney disease (2021) and heart failure (2020) in non-diabetics, both important sources of morbidity and mortality. Despite being an already developed drug with safety data, these repurposings took seven and six years, respectively.
Clinical Trials, Medical Research, Diabetes, Cardiovascular Health, Drug Repurposing
52 points by apsec112 30 days ago | 5 comments
How to Test More Drugs (writingruxandrabio.com)
There comes a time in every biologist’s life when their tech friends will ask, with well-meaning but perceptibly pitiful curiosity, why medical progress is so frustratingly slow.
Science, Biology, Medical Research
23 points by apsec112 30 days ago | 10 comments
Congo mystery disease identified as severe malaria (cbsnews.com)
Congo, Malaria, Health, Disease, Medical Research
6 points by throwup238 30 days ago | 0 comments
Clinical Trials for Drug That Replaces Missing Teeth Underway (sciencealert.com)
People with missing teeth may be able to grow new ones, say Japanese dentists testing a pioneering drug they hope will offer an alternative to dentures and implants.
Dentistry, Medical Research, Regenerative Medicine
4 points by arizen 31 days ago | 2 comments
Ozempic increases risk of debilitating eye condition: studies (sdu.dk)
Two independent studies from the University of Southern Denmark (SDU) show that patients with type 2 diabetes who are treated with the drug Ozempic have an increased risk of developing damage to the optic nerve of the eye, which can lead to severe and permanent loss of vision.
Medical Research, Health, Diabetes, Eye Health
79 points by Erikun 31 days ago | 101 comments
Obesity is down in the US in a decade (bloomberg.com)
Obesity is down in the US for the first time in a decade. A new study suggests weight-loss drugs may explain why.
Obesity, Health, Public Health, United States, Medical Research
6 points by JumpCrisscross 36 days ago | 1 comments
Stimulating parts of the brain can help the paralysed to walk again (economist.com)
The spinal cord is the control cable that connects the brain to the rest of the body. If it is severed, people lose the ability to move their body below the site of the injury. But if it is only partly cut, the brain can sometimes adapt to the damage. Some people who are paralysed by a spinal-cord injury can gradually regain at least a limited ability to walk.
Neuroscience, Medical Research, Paralysis
15 points by bookofjoe 41 days ago | 6 comments
Researchers launch "moonshot" to cure blindness through eye transplants (canoncitydailyrecord.com)
As part of a national “moonshot” to cure blindness, researchers at the CU Anschutz Medical Campus will receive as much as $46 million in federal funding over the next five years to pursue a first-of-its-kind full eye transplantation.
Medical Research, Eye Transplantation, Blindness, Moonshot Projects
134 points by viewtransform 43 days ago | 84 comments
Hypothalamic deep brain stimulation augments walking after spinal cord injury (nature.com)
A spinal cord injury (SCI) disrupts the neuronal projections from the brain to the region of the spinal cord that produces walking, leading to various degrees of paralysis. Here, we aimed to identify brain regions that steer the recovery of walking after incomplete SCI and that could be targeted to augment this recovery.
Neuroscience, Medical Research, Brain Stimulation
67 points by Jimmc414 46 days ago | 11 comments
Twice-Yearly HIV Shot Shows 100% Effectiveness in Women (apnews.com)
It’s been called the closest the world has ever come to a vaccine against the AIDS virus.
HIV, Medical Research, Health, Vaccines
249 points by bear_with_me 46 days ago | 146 comments
New funding could make whole-eye transplants a reality (news.northwestern.edu)
A multi-institutional team of researchers, including two Northwestern University engineers, has received up to $56 million from the Advanced Research Projects Agency for Health (ARPA-H) to help make vision-restoring, whole-eye transplants a reality, the agency announced today.
Biotechnology, Medical Research, Eye Health, Transplantation
11 points by gnabgib 46 days ago | 0 comments
Life-changing cream to treat skin cancer moves closer to reality (uq.edu.au)
A topical cream to help prevent and treat skin cancers in organ transplant patients is a step closer to development.
Medical Research, Cancer Treatment, Skin Cancer
51 points by giuliomagnifico 50 days ago | 4 comments
Sleep regularity and major adverse cardiovascular events (jech.bmj.com)
This study examines the associations between device-measured sleep regularity and the risk of major adverse cardiovascular events (MACE), and aims to determine whether sufficient sleep duration attenuates or eliminates the effects of irregular sleep on MACE risk.
Sleep, Cardiovascular Health, Medical Research, Public Health
93 points by domofutu 51 days ago | 16 comments
Malaria vaccine delivered by a mosquito bite (nature.com)
Scientists have developed a new vaccination strategy for malaria — boosting immunity through bites from mosquitoes carrying a genetically engineered version of the parasite that causes malaria.
Malaria, Vaccines, Biotechnology, Medical Research
145 points by gmays 54 days ago | 226 comments
Progress and prospects of mRNA-based drugs in pre-clinical/clinical applications (nature.com)
In the last decade, messenger ribonucleic acid (mRNA)-based drugs have gained great interest in both immunotherapy and non-immunogenic applications.
mRNA Technology, Biomedicine, Drug Development, Clinical Trials, Medical Research
3 points by lawrenceyan 60 days ago | 0 comments
Severe Covid-19 may shrink cancer tumors, early data suggest (livescience.com)
COVID-19, Cancer, Medical Research, Health
4 points by amichail 61 days ago | 1 comments
Australian scientists thought to be on the verge of curing paralysis (9news.com.au)
Australian scientists believe they are on the verge of uncovering the cure for paralysis, with world-first trials set to use nerve cells from the nose to treat patients.
Australia, Science, Medical Research, Paralysis
16 points by doener 68 days ago | 0 comments
Scientist treated her own cancer with viruses she grew in the lab (nature.com)
A scientist who successfully treated her own breast cancer by injecting the tumour with lab-grown viruses has sparked discussion about the ethics of self-experimentation.
Cancer Treatment, Medical Research, Ethics
692 points by dataminer 70 days ago | 248 comments
Genetic repair via CRISPR can inadvertently introduce other defects (phys.org)
The CRISPR molecular scissors have the potential to revolutionize the treatment of genetic diseases. This is because they can be used to correct specific defective sections of the genome. Unfortunately, however, there is a catch: under certain conditions, the repair can lead to new genetic defects—as in the case of chronic granulomatous disease.
Genetics, CRISPR, Medical Research
111 points by amichail 71 days ago | 65 comments
A 'Crazy' Idea for Treating Autoimmune Diseases Might Work (theatlantic.com)
Lupus has long been considered incurable—but a series of breakthroughs are fueling hope.
Autoimmune Diseases, Medical Research, Health, Lupus
12 points by aarghh 74 days ago | 1 comments
Antibody Drug Conjugates: A frontier in cancer treatment (sagelyhealth.com)
An exciting frontier in cancer treatment over 100 years in the making.
Cancer, Medical Research, Pharmaceuticals, Biotechnology, Treatment
107 points by peerless-app 79 days ago | 44 comments
1374 Days – My Journey with Long Covid (2023) (giorgialupi.com)
For more than three years I’ve been suffering with a debilitating, chronic illness most people call Long Covid.
Long COVID, Health, Personal Experiences, Chronic Illness, Medical Research
87 points by simonebrunozzi 79 days ago | 112 comments
Research reveals new clues to the mysteries of long Covid (ualberta.ca)
Researchers at the University of Alberta have pinpointed two proteins that could serve as markers for identifying patients with long COVID — a discovery that may lead to treatments that will bring better quality of life for the millions of people suffering from the debilitating condition.
Medical Research, COVID-19, Health, Science
33 points by amichail 81 days ago | 5 comments
Survival Analysis Part I: Basic concepts and first analyses (2003) (nature.com)
In many cancer studies, the main outcome under assessment is the time to an event of interest.
Survival Analysis, Cancer Research, Statistics, Medical Research, Biostatistics
38 points by sebg 82 days ago | 9 comments
Stitches with electric charge found to speed up wound healing in rats (medicalxpress.com)
A team of chemical fiber and polymer material researchers in China has found that the use of internally produced, electrically charged sutures can speed up the healing process after surgery in rats.
Medical Research, Biomedical Engineering, Wound Healing
4 points by PaulHoule 84 days ago | 0 comments
Higher triglyceride glucose index linked to increased risk of cognitive decline (psypost.org)
A recent meta-analysis published in the Journal of Affective Disorders revealed that individuals with a higher triglyceride glucose (TyG) index face an increased risk of cognitive decline.
Health, Medical Research, Cognitive Decline, Meta-Analysis
8 points by XzetaU8 85 days ago | 0 comments