Hacker News with Generative AI: Medical Research

AI cracks superbug problem in two days that took scientists years (bbc.co.uk)
A complex problem that took microbiologists a decade to get to the bottom of has been solved in just two days by a new artificial intelligence (AI) tool.
Migraine is more than a headache – a rethink offers hope (nature.com)
Migraine is more than a headache — a radical rethink offers hope to one billion people
How Medical Research Cuts Would Hit Colleges and Hospitals in Every State (nytimes.com)
A proposal by the Trump administration to reduce the size of grants for institutions conducting medical research would have far-reaching effects, and not just for elite universities and the coastal states where many are located.
First patient in UK tests new treatment for loss of sense of smell (theguardian.com)
Smell loss was a defining symptom of Covid, and for some people, a curse. Most people regain their sense of smell as their infection fades, but some never recover. It means not being able to tell if milk is off, if there’s a gas leak or what your newborn baby smells like.
Alzheimer's biomarkers now visible up to a decade ahead of symptoms (newatlas.com)
Researchers at the University of Pittsburgh have devised a biomarker test that can spot small amounts of clumping tau protein in the brain and cerebrospinal fluid, which lead to Alzheimer's disease.
Cheap blood test detects pancreatic cancer before it spreads (nature.com)
Researchers have developed a simple blood test to detect pancreatic cancer before it spreads to other sites in the body.
A former Navy mechanic defied genetic odds of inherited Alzheimer's disease (medicalxpress.com)
Researchers at Washington University School of Medicine in St. Louis have conducted a longitudinal study on an individual carrying the presenilin 2 (PSEN2) p.Asn141Ile mutation, a genetic variant known to cause dominantly inherited Alzheimer's disease (DIAD).
Abandoned in the Middle of Clinical Trials, Because of a Trump Order (nytimes.com)
The stop-work order on U.S.A.I.D.-funded research has left thousands of people with experimental drugs and devices in their bodies, with no access to monitoring or care.
Borrowing nature's blueprint: Scientists replicate bone marrow (phys.org)
Hidden within our bones, marrow sustains life by producing billions of blood cells daily, from oxygen-carrying red cells to immune-boosting white cells. This vital function is often disrupted in cancer patients undergoing chemotherapy or radiation, which can damage the marrow and lead to dangerously low white cell counts, leaving patients vulnerable to infection.
Spinal cord electrical stimulation restores neural function in clinical trial (medicalxpress.com)
A new drug-free, minimally invasive intervention targets the root cause of progressive loss of neural function in spinal muscle atrophy (SMA), an inherited neuromuscular disease.
The legacy of lies in Alzheimer's science (nytimes.com)
Medical advances have beaten back many relentless assassins in recent decades, such as cancer and heart disease.
CDC: Unpublished manuscripts mentioning certain topics must be pulled or revised (insidemedicine.substack.com)
The CDC has instructed its scientists to retract or pause the publication of any research manuscript being considered by any medical or scientific journal, not merely its own internal periodicals, Inside Medicine has learned.
Scientists find links between Alzheimer's, herpes, and head trauma (statnews.com)
At Tufts University in Medford, Mass., researchers loaded a tiny 3D model of the human brain into a plastic shell resting atop a spring-loaded platform.
The Devastating Legacy of Lies in Alzheimer's Science (nytimes.com)
Medical advances have beaten back many relentless assassins in recent decades, such as cancer and heart disease.
Using AI to develop a fuller model of the human brain (magazine.ucsf.edu)
Imagine for a moment that we could create a model of the human brain so precise, so accurate, that it could mimic the brain’s intricate neural patterns in real time. Imagine a “silicon brain,” an artificial neural network so advanced that it could decode a human’s thoughts, restore speech to those who have lost it, and – perhaps one day – even generate a personalized model of the unique brain activity of any individual.
For real, we may be taking blood pressure readings all wrong (arstechnica.com)
According to the study, published in JAMA Cardiology and led by researchers at Harvard, blood pressure readings measured while lying down were significantly better at indicating risks of cardiovascular disease, stroke, heart failure, and death than were seated blood pressure readings alone.
Antibiotics,vaccinations, anti-inflammatory meds linked to reduced dementia risk (medicalxpress.com)
Antibiotics, antivirals, vaccinations and anti-inflammatory medication are associated with reduced risk of dementia, according to new research that looked at health data from over 130 million individuals.
Weight-loss jabs linked to reduced risk of 42 conditions including dementia (theguardian.com)
People with diabetes taking medications found in weight-loss jabs have a reduced risk of 42 conditions, research has found, paving the way for such drugs being used to treat a host of health problems.
Researchers reveal why the lung is a frequent site of cancer metastasis (medicalxpress.com)
More than half of cancer patients in whom the cancer spreads beyond the primary site have lung metastases. What makes the lungs such a tempting place for cancer cells?
Pfizer Stopped Us from Getting Ozempic Decades Ago (nytimes.com)
They called 2023 the year of Ozempic, but it now seems GLP-1 drugs might define an entire decade — or an even longer era.
A Woman with a Rare Gene Mutation Fights to Avoid Her Mother's Fate (nytimes.com)
A mutant gene is coming to steal Linde Jacobs’s mind. Can she find a way to stop it?
Hair Loss Breakthrough: A Sugar Gel Triggers Robust Regrowth (sciencealert.com)
Earlier this year, scientists stumbled upon a potential new treatment for hereditary-patterned baldness, the most common cause of hair loss in both men and women worldwide.
The case for clinical trial abundance (ifp.org)
In 2014, the first SGLT2 inhibitor, dapagliflozin, was approved for patients with Type II diabetes for the control of blood glucose levels. Since then, the list of indications for this class of molecules has expanded to include kidney disease (2021) and heart failure (2020) in non-diabetics, both important sources of morbidity and mortality. Despite being an already developed drug with safety data, these repurposings took seven and six years, respectively.
How to Test More Drugs (writingruxandrabio.com)
There comes a time in every biologist’s life when their tech friends will ask, with well-meaning but perceptibly pitiful curiosity, why medical progress is so frustratingly slow.
Congo mystery disease identified as severe malaria (cbsnews.com)
Clinical Trials for Drug That Replaces Missing Teeth Underway (sciencealert.com)
People with missing teeth may be able to grow new ones, say Japanese dentists testing a pioneering drug they hope will offer an alternative to dentures and implants.
Ozempic increases risk of debilitating eye condition: studies (sdu.dk)
Two independent studies from the University of Southern Denmark (SDU) show that patients with type 2 diabetes who are treated with the drug Ozempic have an increased risk of developing damage to the optic nerve of the eye, which can lead to severe and permanent loss of vision.
Obesity is down in the US in a decade (bloomberg.com)
Obesity is down in the US for the first time in a decade. A new study suggests weight-loss drugs may explain why.
Stimulating parts of the brain can help the paralysed to walk again (economist.com)
The spinal cord is the control cable that connects the brain to the rest of the body. If it is severed, people lose the ability to move their body below the site of the injury. But if it is only partly cut, the brain can sometimes adapt to the damage. Some people who are paralysed by a spinal-cord injury can gradually regain at least a limited ability to walk.
Researchers launch "moonshot" to cure blindness through eye transplants (canoncitydailyrecord.com)
As part of a national “moonshot” to cure blindness, researchers at the CU Anschutz Medical Campus will receive as much as $46 million in federal funding over the next five years to pursue a first-of-its-kind full eye transplantation.