Hacker News with Generative AI: Pharmacology

Some gut bacteria could make certain drugs less effective, study indicates (phys.org)
A study published in Nature Chemistry by researchers from the University of Pittsburgh and Yale University shows how common gut bacteria can metabolize certain oral medications that target cellular receptors called GPCRs, potentially rendering these important drugs less effective.

Medicine, Pharmacology, Microbiology, Health

9 points by pseudolus 23 days ago | 1 comments

First stroke rehabilitation drug discovered in mouse model (medicalxpress.com)
A new study by UCLA Health has discovered what researchers say is the first drug to fully reproduce the effects of physical stroke rehabilitation in model mice.

Medical Research, Neuroscience, Stroke, Pharmacology, Animals

3 points by PaulHoule 30 days ago | 0 comments

Metformin-regulated glucose flux from the circulation to the intestinal lumen (nature.com)
Through a retrospective analysis of existing FDG PET-MRI images, we recently demonstrated that metformin increases the accumulation of FDG in the intestinal lumen, suggesting that metformin stimulates glucose excretion into the intestine. However, the details of this phenomenon remain unclear. We here investigate the detailed dynamics of intestinal glucose excretion, including the rate of excretion and the metabolism of excreted glucose, in both the presence and absence of metformin.

Medicine, Glucose Metabolism, Pharmacology, Intestinal Health, Imaging

3 points by PaulHoule 42 days ago | 0 comments

Antibiotics,vaccinations, anti-inflammatory meds linked to reduced dementia risk (medicalxpress.com)
Antibiotics, antivirals, vaccinations and anti-inflammatory medication are associated with reduced risk of dementia, according to new research that looked at health data from over 130 million individuals.

Medical Research, Dementia, Public Health, Pharmacology

6 points by bikenaga 95 days ago | 0 comments

The Compounding Loophole (astralcodexten.com)
Now that we’ve gone over the pharmacology of the GLP-1 agonists, let’s get back to the economics.

Economics, Pharmacology, Medicine

7 points by paulpauper 96 days ago | 0 comments

Resiniferatoxin (wikipedia.org)

Chemistry, Biology, Pharmacology

5 points by elsewhen 243 days ago | 0 comments

WTH Is Cerebrolysin, Actually? (moreisdifferent.blog)

Neuroscience, Medicine, Pharmacology, Brain Health

83 points by surprisetalk 256 days ago | 58 comments

Cathinone and Psilocybin in Cicada Pathogens (2019) (sciencedirect.com)

Science, Entomology, Pharmacology

13 points by eigenform 356 days ago | 0 comments

CB1 Receptor Negative Allosteric Modulators to Reverse Cannabinoid Toxicity (mdpi.com)