Hacker News with Generative AI: Alzheimer's Disease

Scientists find 16 new Alzheimer's-linked genes using multi-ancestry genome data (psypost.org)
A new study published in Alzheimer’s & Dementia has identified 16 novel genetic regions associated with Alzheimer’s disease by analyzing whole genome sequencing data from a large, ethnically diverse group of individuals.

Alzheimer's Disease, Genetics, Research, Science, Health

6 points by lentoutcry 15 days ago | 0 comments

Some HIV drugs could reduce risk of Alzheimer's by 6-13% (eurekalert.org)
UVA Health scientists are calling for clinical trials testing the potential of HIV drugs called NRTIs to prevent Alzheimer’s disease after discovering that patients taking the drugs are substantially less likely to develop the memory-robbing condition.

Alzheimer's Disease, HIV, Medicine, Research

3 points by MattSayar 29 days ago | 0 comments

Alzheimers could be linked to a common virus (sciencealert.com)
The common cold sore virus, which is often caught in childhood, usually stays in the body for life – quietly dormant in the nerves. Now and then, things like stress, illness or injury can trigger it, bringing on a cold sore in some people.

Health, Viruses, Alzheimer's Disease

11 points by antman 36 days ago | 0 comments

AI helps unravel a cause of Alzheimer’s and identify a therapeutic candidate (today.ucsd.edu)
A new study found that a gene recently recognized as a biomarker for Alzheimer’s disease is actually a cause of it, due to its previously unknown secondary function.

Alzheimer's Disease, Genetics, AI, Therapeutics

319 points by pedalpete 41 days ago | 160 comments

Methylene Blue Address Vascular-Hypometabolism in Alzheimer's Disease (gethealthspan.com)
Alzheimer’s disease (AD) is often associated with amyloid plaques and neurofibrillary tangles, yet growing evidence supports a vascular-hypometabolism hypothesis in which cerebral hypoperfusion and mitochondrial dysfunction—particularly at the level of cytochrome c oxidase—drive early disease processes.

Alzheimer's Disease, Neuroscience, Medical Research, Health

5 points by dtawfik1 41 days ago | 0 comments

One of the country's leading Alzheimer's projects is in jeopardy (nbcnews.com)
A pause to NIH funding has researchers scrambling for contingency plans at the University of Washington’s Alzheimer’s Disease Research Center. The center’s brain bank is preserving more than 4,000 brains for research.

Alzheimer's Disease, Research, Funding, Science, Health

27 points by KittenInABox 54 days ago | 0 comments

Do viruses trigger Alzheimer's? (economist.com)
In the summer of 2024 several groups of scientists published a curious finding: people vaccinated against shingles were less likely to develop dementia than their unvaccinated peers.

Health, Science, Alzheimer's Disease, Vaccines

211 points by helsinkiandrew 76 days ago | 163 comments

Review: Evidence expanding that 40Hz gamma stimulation promotes brain health (picower.mit.edu)
A decade after scientists in The Picower Institute for Learning and Memory at MIT first began testing whether sensory stimulation of the brain’s 40Hz “gamma” frequency rhythms could treat Alzheimer’s disease in mice, a growing evidence base supporting the idea that it can improve brain health—in humans as well as animals—has emerged from the work of labs all over the world.

Neuroscience, Brain Health, Alzheimer's Disease, Research

25 points by XzetaU8 94 days ago | 4 comments

Pair of common viruses may trigger Alzheimer's disease (newatlas.com)
A fascinating collaborative study in 2022, between researchers at the University of Oxford and Tufts University, suggested two common viruses could be working in tandem to trigger the earliest stages of Alzheimer’s disease.

Alzheimer's Disease, Viruses, Science, Health, Research

8 points by dabinat 101 days ago | 0 comments

Decades of Research Misconduct Stalled an Alzheimer's Cure (sciencefriday.com)
In December 2021, I fell into one of the biggest and most disturbing stories of my career. A credible whistleblower with strong credentials in dementia research tipped me to a major case of apparent misconduct in his field. He produced convincing evidence that lab studies at the heart of the dominant hypothesis for the cause of Alzheimer’s disease might have been based on bogus data.

Science, Alzheimer's Disease, Research Misconduct, Medical Research

217 points by sorokod 104 days ago | 83 comments

When is the correct time to diagnose dementia? (theguardian.com)
Pin-prick blood tests that detect possible precursors of Alzheimer’s disease are becoming available – but is it right to label people who will never develop the disease?

Alzheimer's Disease, Medical Diagnosis, Ethics, Healthcare

9 points by bookofjoe 104 days ago | 0 comments

Alzheimer's Disease as Type 3 Diabetes (gethealthspan.com)
Over the past several decades, Alzheimer’s disease (AD) has been predominantly explained through the lens of amyloid-beta plaques and neurofibrillary tangles, yet an emerging paradigm shift increasingly recognizes metabolic dysfunction—specifically, insulin resistance—as a key driver of AD.

Alzheimer's Disease, Diabetes, Neuroscience, Health, Research

13 points by dtawfik1 111 days ago | 3 comments

A former Navy mechanic defied genetic odds of inherited Alzheimer's disease (medicalxpress.com)
Researchers at Washington University School of Medicine in St. Louis have conducted a longitudinal study on an individual carrying the presenilin 2 (PSEN2) p.Asn141Ile mutation, a genetic variant known to cause dominantly inherited Alzheimer's disease (DIAD).

Alzheimer's Disease, Genetics, Medical Research, Health

3 points by pinewurst 115 days ago | 0 comments

The legacy of lies in Alzheimer's science (nytimes.com)
Medical advances have beaten back many relentless assassins in recent decades, such as cancer and heart disease.

Alzheimer's Disease, Medical Research, Science

307 points by apsec112 125 days ago | 210 comments

Scientists find links between Alzheimer's, herpes, and head trauma (statnews.com)
At Tufts University in Medford, Mass., researchers loaded a tiny 3D model of the human brain into a plastic shell resting atop a spring-loaded platform.

Alzheimer's Disease, Neuroscience, Medical Research, Herpes Virus, Head Trauma

223 points by wglb 127 days ago | 80 comments

A Missing Link Between Concussion and Alzheimer's (nautil.us)
Viruses may play a surprising part

Health, Alzheimer's Disease, Concussion, Viruses

61 points by dnetesn 130 days ago | 7 comments

The Devastating Legacy of Lies in Alzheimer's Science (nytimes.com)
Medical advances have beaten back many relentless assassins in recent decades, such as cancer and heart disease.

Alzheimer's Disease, Medical Research, Science

7 points by doctored 132 days ago | 0 comments

Scientists Discover Common Virus Could Be Causing a Type of Alzheimer's (sciencealert.com)
Researchers have discovered a link between a chronic gut infection caused by a common virus and the development of Alzheimer's disease in some people.

Science, Medicine, Alzheimer's Disease, Viruses

5 points by Jimmc414 153 days ago | 3 comments

Blarcamesine for the Treatment of Early Alzheimer's Disease (sciencedirect.com)
There are no approved oral disease-modifying treatments for Alzheimer's disease (AD).

Alzheimer's Disease, Medicine, Research

3 points by doink123 157 days ago | 0 comments

Alzheimer's Mortality Lowest for Taxi, Ambulance Drivers (medpagetoday.com)
Taxi drivers and ambulance drivers -- two groups of people with jobs that require frequent spatial and navigational processing -- had the lowest proportions of deaths attributed to Alzheimer's disease, an analysis of U.S. death certificates showed.

Alzheimer's Disease, Health, Spatial Navigation, Transportation, Science

12 points by speckx 171 days ago | 9 comments

The brain microbiome: could understanding it help prevent dementia? (theguardian.com)
Long thought to be sterile, our brains are now believed to harbour all sorts of micro-organisms, from bacteria to fungi. How big a part do they play in Alzheimer’s and similar diseases?

Neuroscience, Microbiome, Dementia, Alzheimer's Disease

6 points by mudil 174 days ago | 0 comments

Alzheimer's study shows ketone bodies help clear misfolded proteins (genengnews.com)
Ketone bodies are produced by the body to provide fuel during fasting, and are thought to have roles in regulating cellular processes and aging mechanisms beyond energy production.

Alzheimer's Disease, Health, Science, Biology, Neuroscience

181 points by msie 179 days ago | 107 comments

The brain microbiome: could understanding it help prevent dementia? (theguardian.com)
Long thought to be sterile, our brains are now believed to harbour all sorts of micro-organisms, from bacteria to fungi. How big a part do they play in Alzheimer’s and similar diseases?

Microbiology, Neuroscience, Dementia, Alzheimer's Disease

7 points by pseudolus 184 days ago | 0 comments

Glyphosate exacerbates neuroinflammation and Alzheimer's disease-like pathology (biomedcentral.com)
Glyphosate use in the United States (US) has increased each year since the introduction of glyphosate-tolerant crops in 1996, yet little is known about its effects on the brain.

Science, Health, Alzheimer's Disease, Pesticides

54 points by gnabgib 185 days ago | 21 comments

Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes (nbcnews.com)
Semaglutide, the active ingredient in Ozempic and Wegovy, appeared to reduce the risk of Alzheimer’s disease in people with Type 2 diabetes, according to a study published Thursday in the journal Alzheimer’s & Dementia.

Health, Alzheimer's Disease, Pharmaceuticals

98 points by benchtobedside 226 days ago | 204 comments

Six top Alzheimer's researchers accused of fraud (threadreaderapp.com)
List of high-level Alzheimer's researchers accused of credible fraud:🧵

Alzheimer's Disease, Science, Research, Fraud, Healthcare

65 points by apsec112 229 days ago | 29 comments

The brain has its own microbiome (newscientist.com)
Neuroscientists have been surprised to discover that the human brain is teeming with microbes, and we are beginning to suspect they could play a role in neurodegenerative disorders like Alzheimer's

Neuroscience, Microbiome, Health, Alzheimer's Disease

48 points by janandonly 245 days ago | 47 comments

Memory Loss Isn't the Only Sign of Dementia (nytimes.com)
Memory loss is the most well-known symptom of dementia, particularly Alzheimer’s disease. But experts say there are other warning signs that can signal early brain changes — ones that are especially important for types of dementia where forgetfulness is not the primary symptom.

Health, Dementia, Alzheimer's Disease, Cognitive Decline

14 points by rawgabbit 253 days ago | 2 comments

Molecule restores cognition and memory in Alzheimer's disease mouse study (newsroom.ucla.edu)