Hacker News with Generative AI: Alzheimer's Disease

One of the country's leading Alzheimer's projects is in jeopardy (nbcnews.com)
A pause to NIH funding has researchers scrambling for contingency plans at the University of Washington’s Alzheimer’s Disease Research Center. The center’s brain bank is preserving more than 4,000 brains for research.

Alzheimer's Disease, Research, Funding, Science, Health

27 points by KittenInABox 12 days ago | 0 comments

Do viruses trigger Alzheimer's? (economist.com)
In the summer of 2024 several groups of scientists published a curious finding: people vaccinated against shingles were less likely to develop dementia than their unvaccinated peers.

Health, Science, Alzheimer's Disease, Vaccines

211 points by helsinkiandrew 34 days ago | 163 comments

Review: Evidence expanding that 40Hz gamma stimulation promotes brain health (picower.mit.edu)
A decade after scientists in The Picower Institute for Learning and Memory at MIT first began testing whether sensory stimulation of the brain’s 40Hz “gamma” frequency rhythms could treat Alzheimer’s disease in mice, a growing evidence base supporting the idea that it can improve brain health—in humans as well as animals—has emerged from the work of labs all over the world.

Neuroscience, Brain Health, Alzheimer's Disease, Research

25 points by XzetaU8 52 days ago | 4 comments

Pair of common viruses may trigger Alzheimer's disease (newatlas.com)
A fascinating collaborative study in 2022, between researchers at the University of Oxford and Tufts University, suggested two common viruses could be working in tandem to trigger the earliest stages of Alzheimer’s disease.

Alzheimer's Disease, Viruses, Science, Health, Research

8 points by dabinat 58 days ago | 0 comments

Decades of Research Misconduct Stalled an Alzheimer's Cure (sciencefriday.com)
In December 2021, I fell into one of the biggest and most disturbing stories of my career. A credible whistleblower with strong credentials in dementia research tipped me to a major case of apparent misconduct in his field. He produced convincing evidence that lab studies at the heart of the dominant hypothesis for the cause of Alzheimer’s disease might have been based on bogus data.

Science, Alzheimer's Disease, Research Misconduct, Medical Research

217 points by sorokod 61 days ago | 83 comments

When is the correct time to diagnose dementia? (theguardian.com)
Pin-prick blood tests that detect possible precursors of Alzheimer’s disease are becoming available – but is it right to label people who will never develop the disease?

Alzheimer's Disease, Medical Diagnosis, Ethics, Healthcare

9 points by bookofjoe 61 days ago | 0 comments

Alzheimer's Disease as Type 3 Diabetes (gethealthspan.com)
Over the past several decades, Alzheimer’s disease (AD) has been predominantly explained through the lens of amyloid-beta plaques and neurofibrillary tangles, yet an emerging paradigm shift increasingly recognizes metabolic dysfunction—specifically, insulin resistance—as a key driver of AD.

Alzheimer's Disease, Diabetes, Neuroscience, Health, Research

13 points by dtawfik1 69 days ago | 3 comments

A former Navy mechanic defied genetic odds of inherited Alzheimer's disease (medicalxpress.com)
Researchers at Washington University School of Medicine in St. Louis have conducted a longitudinal study on an individual carrying the presenilin 2 (PSEN2) p.Asn141Ile mutation, a genetic variant known to cause dominantly inherited Alzheimer's disease (DIAD).

Alzheimer's Disease, Genetics, Medical Research, Health

3 points by pinewurst 73 days ago | 0 comments

The legacy of lies in Alzheimer's science (nytimes.com)
Medical advances have beaten back many relentless assassins in recent decades, such as cancer and heart disease.

Alzheimer's Disease, Medical Research, Science

307 points by apsec112 82 days ago | 210 comments

Scientists find links between Alzheimer's, herpes, and head trauma (statnews.com)
At Tufts University in Medford, Mass., researchers loaded a tiny 3D model of the human brain into a plastic shell resting atop a spring-loaded platform.

Alzheimer's Disease, Neuroscience, Medical Research, Herpes Virus, Head Trauma

223 points by wglb 84 days ago | 80 comments

A Missing Link Between Concussion and Alzheimer's (nautil.us)
Viruses may play a surprising part

Health, Alzheimer's Disease, Concussion, Viruses

61 points by dnetesn 88 days ago | 7 comments

The Devastating Legacy of Lies in Alzheimer's Science (nytimes.com)
Medical advances have beaten back many relentless assassins in recent decades, such as cancer and heart disease.

Alzheimer's Disease, Medical Research, Science

7 points by doctored 89 days ago | 0 comments

Scientists Discover Common Virus Could Be Causing a Type of Alzheimer's (sciencealert.com)
Researchers have discovered a link between a chronic gut infection caused by a common virus and the development of Alzheimer's disease in some people.

Science, Medicine, Alzheimer's Disease, Viruses

5 points by Jimmc414 110 days ago | 3 comments

Blarcamesine for the Treatment of Early Alzheimer's Disease (sciencedirect.com)
There are no approved oral disease-modifying treatments for Alzheimer's disease (AD).

Alzheimer's Disease, Medicine, Research

3 points by doink123 114 days ago | 0 comments

Alzheimer's Mortality Lowest for Taxi, Ambulance Drivers (medpagetoday.com)
Taxi drivers and ambulance drivers -- two groups of people with jobs that require frequent spatial and navigational processing -- had the lowest proportions of deaths attributed to Alzheimer's disease, an analysis of U.S. death certificates showed.

Alzheimer's Disease, Health, Spatial Navigation, Transportation, Science

12 points by speckx 129 days ago | 9 comments

The brain microbiome: could understanding it help prevent dementia? (theguardian.com)
Long thought to be sterile, our brains are now believed to harbour all sorts of micro-organisms, from bacteria to fungi. How big a part do they play in Alzheimer’s and similar diseases?

Neuroscience, Microbiome, Dementia, Alzheimer's Disease

6 points by mudil 131 days ago | 0 comments

Alzheimer's study shows ketone bodies help clear misfolded proteins (genengnews.com)
Ketone bodies are produced by the body to provide fuel during fasting, and are thought to have roles in regulating cellular processes and aging mechanisms beyond energy production.

Alzheimer's Disease, Health, Science, Biology, Neuroscience

181 points by msie 136 days ago | 107 comments

The brain microbiome: could understanding it help prevent dementia? (theguardian.com)
Long thought to be sterile, our brains are now believed to harbour all sorts of micro-organisms, from bacteria to fungi. How big a part do they play in Alzheimer’s and similar diseases?

Microbiology, Neuroscience, Dementia, Alzheimer's Disease

7 points by pseudolus 142 days ago | 0 comments

Glyphosate exacerbates neuroinflammation and Alzheimer's disease-like pathology (biomedcentral.com)
Glyphosate use in the United States (US) has increased each year since the introduction of glyphosate-tolerant crops in 1996, yet little is known about its effects on the brain.

Science, Health, Alzheimer's Disease, Pesticides

54 points by gnabgib 142 days ago | 21 comments

Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes (nbcnews.com)
Semaglutide, the active ingredient in Ozempic and Wegovy, appeared to reduce the risk of Alzheimer’s disease in people with Type 2 diabetes, according to a study published Thursday in the journal Alzheimer’s & Dementia.

Health, Alzheimer's Disease, Pharmaceuticals

98 points by benchtobedside 183 days ago | 204 comments

Six top Alzheimer's researchers accused of fraud (threadreaderapp.com)
List of high-level Alzheimer's researchers accused of credible fraud:🧵

Alzheimer's Disease, Science, Research, Fraud, Healthcare

65 points by apsec112 187 days ago | 29 comments

The brain has its own microbiome (newscientist.com)
Neuroscientists have been surprised to discover that the human brain is teeming with microbes, and we are beginning to suspect they could play a role in neurodegenerative disorders like Alzheimer's

Neuroscience, Microbiome, Health, Alzheimer's Disease

48 points by janandonly 203 days ago | 47 comments

Memory Loss Isn't the Only Sign of Dementia (nytimes.com)
Memory loss is the most well-known symptom of dementia, particularly Alzheimer’s disease. But experts say there are other warning signs that can signal early brain changes — ones that are especially important for types of dementia where forgetfulness is not the primary symptom.

Health, Dementia, Alzheimer's Disease, Cognitive Decline

14 points by rawgabbit 211 days ago | 2 comments

Molecule restores cognition and memory in Alzheimer's disease mouse study (newsroom.ucla.edu)

Alzheimer's Disease, Neuroscience, Medical Research, Mouse Studies

84 points by geox 245 days ago | 23 comments

The Cause of Alzheimer's Might Not Be Amyloid (scitechdaily.com)

Alzheimer's Disease, Neuroscience, Medical Research

15 points by bookofjoe 252 days ago | 3 comments

Molecule restores cognition, memory in Alzheimer's disease model mice (uclahealth.org)

Alzheimer's Disease, Neuroscience, Medical Research, Mice Studies

134 points by amichail 260 days ago | 66 comments

A blood test accurately diagnosed Alzheimer's 90% of the time, study finds (nytimes.com)