Hacker News with Generative AI: Pharmaceuticals

Eli Lilly will soon release key data on its weight loss pill orforglipron (cnbc.com)
Breakthrough stroke drug heals the brain to restore movement (newatlas.com)
There's newfound hope for stroke patients in recovery, with what researchers believe is the very first drug that can comprehensively deliver rehabilitation without the need for challenging long-term physical therapy.
After 5 Years, FDA Finally Inspected Indian Drug Factory Linked to U.S. Deaths (propublica.org)
The Food and Drug Administration has found problems at an Indian factory that makes generic drugs for American patients, including one medication that was manufactured there and has been linked to at least eight deaths, federal records show.
American pharmaceutical companies aren't paying tax in the U.S. (cfr.org)
The 2024 10-K reports of America’s largest pharmaceutical companies show that they continue to avoid paying much, if any, U.S. corporate income tax.
The Ozempocalypse Is Nigh (astralcodexten.com)
Three GLP-1 drugs are approved for weight loss in the United States:
New anti-obesity drugs outperform Ozempic (elpais.com)
For decades, people who are overweight have been given simple advice: move more and eat less. However, in more than 80% of cases, this approach only works in the short term.
New anti-obesity drugs outperform Ozempic (elpais.com)
For decades, people who are overweight have been given simple advice: move more and eat less. However, in more than 80% of cases, this approach only works in the short term.
Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects (medicalxpress.com)
A naturally occurring molecule identified by Stanford Medicine researchers appears similar to semaglutide—also known as Ozempic—in suppressing appetite and reducing body weight.
GLP-1 drugs: An economic disruptor? (2024) (wildfirelabs.substack.com)
In 2021, Lisa Chen, a software engineer, started a new weight-loss medication. Then, something interesting happened at her local coffee shop, her employer's healthcare costs, and the global economy.
A Chinese company made a drug that beat the biggest-selling medicine (cnn.com)
Hotdogs and motorways: The ripples created by Denmark's Ozempic and Wegovy boom (bbc.com)
American demand for weight-loss drugs is supercharging Denmark’s economy and transforming a small Danish community into an unlikely boomtown.
China's leap in pharma: slow and fast trends behind its rise (alexkesin.com)
In 2024, China’s pharmaceutical industry made headlines. To some extent – it was one of the biggest shocks of last year. Once known primarily for generic drugs and contract manufacturing, China is now producing innovative therapies, attracting major investments, and striking high-profile deals with Western pharma – something few expected only a decade ago would happen.
Ask HN: Opinion on efforts to find prior art on outrageous priced drugs (ycombinator.com)
It's not just AI. China's medicines are surprising the world, too (economist.com)
It’s not just AI. China’s medicines are surprising the world, too
The lottery of the snakebite antivenom industry (theguardian.com)
Investigation reveals ineffective products being sold across Africa, with poor regulation and shortage of effective medication leading to needless deaths
New obesity drugs are coming: these are the ones to watch (nature.com)
Dozens of new obesity drugs are coming: these are the ones to watch
The Physicians Are Healing Themselves, with Ozempic (nytimes.com)
At cardiology conferences and diabetes meetings, doctors can’t help noticing that thin seems to be very in.
How a Leftist Activist Group Helped Torpedo a Psychedelic Therapy (nytimes.com)
After more than three decades of planning and a $250 million investment, Lykos Therapeutics’ application for the first psychedelic drug to reach federal regulators was expected to be a shoo-in.
US drug agency approves potent painkiller – the first non-opioid in decades (nature.com)
The FDA’s nod for suzetrigine bolsters confidence in the pharmaceutical industry’s strategy to target sodium channels.
FDA approves Vertex's non-opioid painkiller, first new pain medicine in decades (cnbc.com)
FDA Approves Novel Non-Opioid Treatment for Moderate to Acute Pain (fda.gov)
Today, the U.S. Food and Drug Administration approved Journavx (suzetrigine) 50 milligram oral tablets, a first-in-class non-opioid analgesic, to treat moderate to severe acute pain in adults.
FDA Approves drug to treat pain without opioid effects (nytimes.com)
The Food and Drug Administration approved a new medication Thursday to treat pain from an injury or surgery.
Weight-loss surgery down 25 percent as anti-obesity drug use soars (2024) (news.harvard.edu)
A new study examining a large sample of privately insured patients with obesity found that use of drugs such as Ozempic and Wegovy as anti-obesity medications more than doubled from 2022 to 2023. During that same period, there was a 25.6 percent decrease in patients undergoing metabolic bariatric surgery to treat obesity.
Ozempic and Wegovy are selected for Medicare's price negotiations (apnews.com)
Popular weight loss and diabetes drugs like Ozempic and Wegovy have been added to Medicare’s list of medications that will be negotiated directly between the government and drug manufacturers, the Biden administration said Friday.
Ask HN: Why do some medicines come as pills and others as capsules? (ycombinator.com)
Ask HN: Why do some medicines come as pills and others as capsules?
Pfizer Stopped Us from Getting Ozempic Decades Ago (nytimes.com)
They called 2023 the year of Ozempic, but it now seems GLP-1 drugs might define an entire decade — or an even longer era.
McKinsey and Company to pay $650M for role in opioid crisis (npr.org)
The global consulting firm McKinsey and Company Friday agreed to pay $650 million to settle a federal probe into its role in helping "turbocharge" sales of the highly addictive opioid painkiller OxyContin for Purdue Pharma, the U.S. Justice Department announced on Friday.
The benefits of Ozempic and its kin may extend far beyond weight loss (sciencenews.org)
This year, the popularity of the diabetes and weight-loss drug semaglutide has continued to surge. You’ve probably seen ads on social media or heard from friends who’ve tried top-selling brand-name versions, Ozempic and the higher-dose variety Wegovy (SN: 6/29/24, p. 5), or read accounts of people microdosing these drugs.
Weight loss drugs may also treat addiction, Alzheimer's, and heart disease (arstechnica.com)
Pharmaceutical companies are already cashing in on their other health benefits.
Why Recursion Pharmaceuticals abandoned cell painting for brightfield imaging (owlposting.com)
At this point, you’d be hard pressed to not have heard of Recursion Pharmaceuticals.