Hacker News with Generative AI: Psychedelics

Toward a Unified Model of the Brain Action of Psychedelics (aspetjournals.org)
This paper formulates the action of psychedelics by integrating the free-energy principle and entropic brain hypothesis.
Human brain changes after first psilocybin use (biorxiv.org)
Psychedelics have robust effects on acute brain function and long-term behavior but whether they also cause enduring functional and anatomical brain changes is unknown.
Psychedelic Mushrooms Are Getting Much, Much Stronger (wired.com)
Cultivators are turning to genetic sequencing and cellular-manipulation techniques to breed highly potent mushrooms—leaving some unprepared psychonauts in distress.
Psychedelics Reduce Anxiety Without Hallucinations (neurosciencenews.com)
New research has pinpointed the specific brain region and neuron type responsible for reducing anxiety using the psychedelic drug DOI, without triggering hallucinations.
Software development for the DMT headspace (smoothbrains.net)
I would hazard a guess that some readers of this blog might already be familiar with the delightful Scott Alexander story, Universal Love, Said The Cactus Person – in which the unnamed protagonist asks a couple of DMT entities to factorise a large integer:
Magic mushroom chocolates are having a moment. But do they contain mushrooms? (latimes.com)
A scientist took a psychedelic drug – and watched his own brain 'fall apart' (npr.org)
New study shows reactions in the brain in people who were given psilocybin (nytimes.com)
Mexico may legalize magic mushrooms (latimes.com)
Effects of psychedelics on neurogenesis and brain plasticity A systematic review (biorxiv.org)
Tripping on Xenon Gas (2023) (tripsitter.substack.com)
Psychedelics are challenging the standard of randomized controlled trials (theatlantic.com)
Psychedelics could treat some of the worst chronic pain in the world (vox.com)
Therapists report significant psychological risks in psilocybin-assisted treat (psypost.org)
Arizona Church Reaches Settlement with Federal Agencies to Use Ayahuasca (chacruna.net)
Bicycle Day (Psychedelic Holiday) (wikipedia.org)
Psychiatric risks for worsened mental health after psychedelic use (sagepub.com)
Psychedelics and trauma: How one survivor of festival terrorism 'felt no fear' (smh.com.au)