Hacker News with Generative AI: Biomedicine

Micro nutrients as immunomodulators in the ageing population (biomedcentral.com)
Immunosenescence, the slow degradation of immune function over time that is a hallmark and driver of aging, makes older people much more likely to be killed by common infections (such as flu) than young adults, but it also contributes greatly to rates of chronic inflammation in later life.

Immunology, Aging, Health, Biomedicine

4 points by haltingproblem 16 days ago | 0 comments

Nucleotide Transformer: building robust foundation models for human genomics (nature.com)
The prediction of molecular phenotypes from DNA sequences remains a longstanding challenge in genomics, often driven by limited annotated data and the inability to transfer learnings between tasks.

Genomics, Machine Learning, Biomedicine, Foundation Models

57 points by bookofjoe 47 days ago | 9 comments

Progress and prospects of mRNA-based drugs in pre-clinical/clinical applications (nature.com)
In the last decade, messenger ribonucleic acid (mRNA)-based drugs have gained great interest in both immunotherapy and non-immunogenic applications.

mRNA Technology, Biomedicine, Drug Development, Clinical Trials, Medical Research

3 points by lawrenceyan 60 days ago | 0 comments

Why computational predictive toxicology is hard (owlposting.com)
There are now (claimed) foundation models for protein sequences, DNA sequences, RNA sequences, molecules, scRNA-seq, chromatin accessibility, pathology slides, medical images, electronic health records, and clinical free-text. It’s a dizzying rate of progress.