Hacker News with Generative AI: Proteins

Hallucination of closed repeat proteins containing central pockets (2023) (nature.com)
Inspired by these proteins, we devised a deep-learning-based approach to broadly exploring the space of closed repeat proteins starting from only a specification of the repeat number and length.

Proteins, Deep Learning, Science, Biology, AI

8 points by bookofjoe 20 days ago | 0 comments

Show HN: ESM C, setting a new state of the art for protein language models (evolutionaryscale.ai)
Today we’re introducing ESM Cambrian, a next generation language model trained on protein sequences at the scale of life on Earth. ESM C models define a new state of the art for protein representation learning.

Machine Learning, Biology, Proteins, Scientific Research

11 points by ebetica0 45 days ago | 1 comments

Transcript errors generate amyloid-like proteins in human cells (nature.com)
Aging is characterized by the accumulation of proteins that display amyloid-like behavior. However, the molecular mechanisms by which these proteins arise remain unclear. Here, we demonstrate that amyloid-like proteins are produced in a variety of human cell types, including stem cells, brain organoids and fully differentiated neurons by mistakes that occur in messenger RNA molecules.

Science, Biology, Aging, Proteins, Cellular Biology

4 points by bookofjoe 99 days ago | 0 comments

Understudied protein blobs have global effects on cell biochemistry (phys.org)
Most biological chemistry research has historically focused on the obvious cogs of machinery that keep life moving. Folding proteins, genetic activity and electrical signaling pathways are the easiest targets for finding irregularities that lead to disease.

Biology, Biochemistry, Science, Proteins

51 points by PaulHoule 120 days ago | 12 comments

How colorful ribbon diagrams became the face of proteins (quantamagazine.org)
Jane Richardson never considered herself an artist. Then, in the late 1970s, the structural biologist found herself in need of some colored pencils, pastels and sketching paper.

Science, Biology, Proteins, Art, Visualizations

53 points by gmays 134 days ago | 3 comments

Alternate RNA decoding results in stable and abundant proteins in mammals (biorxiv.org)

RNA, Biology, Genetics, Proteins, Mammals

3 points by apsec112 143 days ago | 0 comments

Colorful Ribbon Diagrams Became the Face of Proteins (quantamagazine.org)

Science, Biology, Visualization, Proteins

9 points by Brajeshwar 146 days ago | 0 comments

Largest protein yet discovered builds algal toxins (phys.org)

Biology, Science, Proteins, Algae, Toxins

58 points by PaulHoule 151 days ago | 15 comments

Bacteria found to produce proteins that act like antifreeze (phys.org)

Biology, Science, Proteins, Antifreeze

11 points by gmays 203 days ago | 1 comments

ESM3 – a multimodal generative protein language model (evolutionaryscale.ai)

Generative AI, Language Models, Biology, Proteins

11 points by ebetica0 207 days ago | 2 comments