Is SaaS a good business model for drug‑discovery companies?
(liorz.github.io)
In 2024 the Nobel Prize in Chemistry went to David Baker, Demis Hassabis, and John Jumper for their groundbreaking advances in computational protein design and protein‑structure prediction. Their achievements—most famously the AlphaFold2 model—have sparked a wave of enthusiasm for applying “foundation models” to biology.
In 2024 the Nobel Prize in Chemistry went to David Baker, Demis Hassabis, and John Jumper for their groundbreaking advances in computational protein design and protein‑structure prediction. Their achievements—most famously the AlphaFold2 model—have sparked a wave of enthusiasm for applying “foundation models” to biology.
Show HN: Too Many Business Ideas? stop choosing, launch all of them, FAST&FREE
(starterpilot.com)
Turn Your Idea Into a Business 10x Faster.
Turn Your Idea Into a Business 10x Faster.
Earthly Shutting Down Earthfiles
(earthly.dev)
In the next three months, we will be phasing out our Earthly Satellite commercial services, including the Earthly Cloud Satellites, Self-Hosted Satellites, and BYOC Satellites, together with their respective free tiers. We are also phasing out Earthly Cloud Secrets and Logs.
In the next three months, we will be phasing out our Earthly Satellite commercial services, including the Earthly Cloud Satellites, Self-Hosted Satellites, and BYOC Satellites, together with their respective free tiers. We are also phasing out Earthly Cloud Secrets and Logs.
Two Years of Rust
(borretti.me)
I recently wrapped up a job where I spent the last two years writing the backend of a B2B SaaS product in Rust, so now is the ideal time to reflect on the experience and write about it.
I recently wrapped up a job where I spent the last two years writing the backend of a B2B SaaS product in Rust, so now is the ideal time to reflect on the experience and write about it.
Domain Sniped on Launch Day
(kill-saas.com)
I created repository for my project for launching open source SaaS alternatives KillSaaS and started developing the project, pushing code changes, etc. After investing some development time (primarily by vibe coding with Windsurf), it was time to launch the project.
I created repository for my project for launching open source SaaS alternatives KillSaaS and started developing the project, pushing code changes, etc. After investing some development time (primarily by vibe coding with Windsurf), it was time to launch the project.
Why Kagi launched "no use, no pay"
(getlago.substack.com)
Paying for a SaaS subscription you don’t use sucks. Sure, I don’t use that shameful cupboard with the ice cream maker, sous-vide device and electric ham-cutter either, but at least those things don’t charge me again!
Paying for a SaaS subscription you don’t use sucks. Sure, I don’t use that shameful cupboard with the ice cream maker, sous-vide device and electric ham-cutter either, but at least those things don’t charge me again!
Launch HN: Augento (YC W25) – Fine-tune your agents with reinforcement learning
(ycombinator.com)
Hi HN, we’re the cofounders of Augento (https://augento.ai/). We’re building Deepseek R1-like fine-tuning as a service. You connect your agent, tell us when it’s right or wrong, and we deliver an LLM optimized for that agent.
Hi HN, we’re the cofounders of Augento (https://augento.ai/). We’re building Deepseek R1-like fine-tuning as a service. You connect your agent, tell us when it’s right or wrong, and we deliver an LLM optimized for that agent.
Oracle attempt to hide cybersecurity incident from customers?
(doublepulsar.com)
Being a provider of cloud SaaS (Software-as-a-service) solutions requires certain cybersecurity responsibilities — including being transparent and open. The moment where this is tested at Oracle has arrived, as they have a serious cybersecurity incident playing out in a service they manage for customers.
Being a provider of cloud SaaS (Software-as-a-service) solutions requires certain cybersecurity responsibilities — including being transparent and open. The moment where this is tested at Oracle has arrived, as they have a serious cybersecurity incident playing out in a service they manage for customers.
Show HN: One-Click GA/GTM Tracking Plan Generator for SaaS Teams
(jtracking.ai)
AI-powered JTracking generates expert event tracking plans for Google Analytics (GA) and enables deployment to Google Tag Manager (GTM) in just one click!
AI-powered JTracking generates expert event tracking plans for Google Analytics (GA) and enables deployment to Google Tag Manager (GTM) in just one click!
It's five grand a day to miss our S3 exit
(world.hey.com)
We're spending just shy of $1.5 million/year on AWS S3 at the moment to host files for Basecamp, HEY, and everything else.
We're spending just shy of $1.5 million/year on AWS S3 at the moment to host files for Basecamp, HEY, and everything else.
It's five grand a day to miss our S3 exit
(world.hey.com)
We're spending just shy of $1.5 million/year on AWS S3 at the moment to host files for Basecamp, HEY, and everything else.
We're spending just shy of $1.5 million/year on AWS S3 at the moment to host files for Basecamp, HEY, and everything else.
"Vibe Coding" is a dangerous fantasy
(nmn.gl)
Last week, X exploded when a “vibe coder” announced his SaaS was under attack.
Last week, X exploded when a “vibe coder” announced his SaaS was under attack.
Vibe Coding Is a Dangerous Fantasy
(nmn.gl)
Last week, X exploded when a “vibe coder” announced his SaaS was under attack.
Last week, X exploded when a “vibe coder” announced his SaaS was under attack.
How I Stay Motivated Working on My Solo SaaS (When It Feels Like Nobody Cares)
(ycombinator.com)
I’ve been grinding on my solo project—a little app to help remote workers find coworking spots nearby—for months, and some days it feels like I’m yelling into the void.
I’ve been grinding on my solo project—a little app to help remote workers find coworking spots nearby—for months, and some days it feels like I’m yelling into the void.
Going from an Idea to MVP in Weeks: PromptPanda's Launch(es)
(opensaas.sh)
Did you know that most co-founders meet each other through work? Lander Willem met his friend and co-founder Bram Billiet while they were working at the local venture fund. They both shared the love towards LLMs and got the idea to kickstart their SaaS after experiencing the same pain points with managing and versioning prompts.
Did you know that most co-founders meet each other through work? Lander Willem met his friend and co-founder Bram Billiet while they were working at the local venture fund. They both shared the love towards LLMs and got the idea to kickstart their SaaS after experiencing the same pain points with managing and versioning prompts.
Tell HN: SaaS Is the New SEO
(ycombinator.com)
With advent of modern web and it's centralization, many niche platforms died.
With advent of modern web and it's centralization, many niche platforms died.
So you wanna go on prem (2016)
(lusis.org)
If you run a successful SaaS platform, at some point someone is going to come to you with the question: can I run it myself?
If you run a successful SaaS platform, at some point someone is going to come to you with the question: can I run it myself?
Launch HN: Sift Dev (YC W25) – AI-Powered Datadog Alternative
(ycombinator.com)
Hi HN! We're Kaushik and Ishir. We’re building SiftDev (https://runsift.com/), an intelligent logging tool that understands your observability data in real time, automatically identifies anomalies, and lets you interact with your logs through natural language queries.
Hi HN! We're Kaushik and Ishir. We’re building SiftDev (https://runsift.com/), an intelligent logging tool that understands your observability data in real time, automatically identifies anomalies, and lets you interact with your logs through natural language queries.
Ask HN: How do you handle VAT / Sales Tax accounting as B2C SaaS?
(ycombinator.com)
Hey! I run a B2C SaaS and I use Stripe for all of my sales (subscriptions).
Hey! I run a B2C SaaS and I use Stripe for all of my sales (subscriptions).
Show HN: PG-Capture – a better way to sync Postgres with Algolia (or Elastic)
(onrender.com)
Schema-based Change-Data-Capture for Postgres
Schema-based Change-Data-Capture for Postgres
Keeping our free tier sustainable by preventing abuse
(geocod.io)
While many SaaS businesses have started to remove their free tiers due to abuse, we are determined to continuing to provide a free tier for our standard service.
While many SaaS businesses have started to remove their free tiers due to abuse, we are determined to continuing to provide a free tier for our standard service.
Ask HN: Small Ideas vs. Big Ideas?
(ycombinator.com)
I've been thinking about this one for a while, does it make sense to work on small ideas? Something like a utility a PDF converter or a small game and attempt to make it into an asset generating $10K - $30K in MRR? Or is it better to aim for building something as big as you can?
I've been thinking about this one for a while, does it make sense to work on small ideas? Something like a utility a PDF converter or a small game and attempt to make it into an asset generating $10K - $30K in MRR? Or is it better to aim for building something as big as you can?
Ask HN: Is SaaS Dead?
(ycombinator.com)
It seems like every CRUD application under the sun has been built, and it is difficult to carve out any value that can be productized.
It seems like every CRUD application under the sun has been built, and it is difficult to carve out any value that can be productized.
Ask HN: What do you run instead of Datadog?
(ycombinator.com)
Datadog has turned into an ever loving piece of shit. I am sick of their sales team grabbing us by the ankles and "Accidentally" charging for services we don't use. Now, this morning they changed something with their AWS integration that is causing 10X the API calls against our accounts (and thus, 10X guardduty costs on our end analyzing those API requests).
Datadog has turned into an ever loving piece of shit. I am sick of their sales team grabbing us by the ankles and "Accidentally" charging for services we don't use. Now, this morning they changed something with their AWS integration that is causing 10X the API calls against our accounts (and thus, 10X guardduty costs on our end analyzing those API requests).